Pacritinib (SB1518)

Catalog No.: A12694
JAK2/FLT3 inhibitor
Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.
Grouped product items
Product Name Price Stock Qty
Pacritinib (SB1518) 5mg
$70.00
In stock
Pacritinib (SB1518) 10mg
$100.00
In stock
Pacritinib (SB1518) 25mg
$180.00
In stock
Pacritinib (SB1518) 50mg
$260.00
In stock
Pacritinib (SB1518) 10mM * 1mL in DMSO
$248.00
In stock
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Adooq Products cited in reputable paper
Adooq's Pacritinib (SB1518) has been cited by 1 publications
  • Daniel Doheny, .et al. , Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
  • Biological Activity
    Discription Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.
    Targets
    Target Value
    Product Information
    Catalog Num A12694
    Formula C28H32N4O3
    Molecular Weight 472.58
    CAS Number 937272-79-2
    SMILES C1CCN(C1)CCOC2=C3COC/C=C/COCC4=CC=CC(=C4)C5=NC(=NC=C5)NC(=C3)C=C2
    Synonyms SB-1518; SB 1518
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO Warmed: 10 mg/mL (21.15 mM)
    Water Insoluble
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.16 mL 105.8 mL 211.6 mL
    0.5 mM 4.23 mL 21.16 mL 42.32 mL
    1 mM 2.12 mL 10.58 mL 21.16 mL
    5 mM 0.42 mL 2.12 mL 4.23 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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