3-deazaneplanocin A HCl (DZNep HCl)

Catalog No.: A13947
EZH2 inhibitor
3-deazaneplanocin A, also known as DZNep, is a well-known histone methyltransferase inhibitor, which disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma.
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Product Name Price Stock Qty
3-deazaneplanocin A HCl 2mg
$150.00
In stock
3-deazaneplanocin A HCl 5mg
$300.00
In stock
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Biological Activity
Discription 3-deazaneplanocin A, also known as DZNep, is a well-known histone methyltransferase inhibitor, which disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma.
Targets
Target Value
Product Information
Catalog Num A13947
Formula C12H15ClN4O3
Molecular Weight 298.73
CAS Number 120964-45-6
SMILES C1=CN=C(C2=C1N(C=N2)[C@@H]3C=C([C@H]([C@H]3O)O)CO)N.Cl
Synonyms DZNep, NSC 617989
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 49 mg/mL (164.03 mM)
Water 49 mg/mL (164.03 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.48 mL 167.38 mL 334.75 mL
0.5 mM 6.7 mL 33.48 mL 66.95 mL
1 mM 3.35 mL 16.74 mL 33.48 mL
5 mM 0.67 mL 3.35 mL 6.7 mL
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