DMXAA (ASA404, Vadimezan)

Catalog No.: A10324

Vascular Disrupting Agent (VDA)

DMXAA (ASA404, Vadimezan)

DMXAA (ASA404, Vadimezan) Chemical Structure

CAS NO. 117570-53-3

DMXAA (ASA404) is a tumor-vascular disrupting agent (tumor-VDA) that attacks the blood supply of a cancerous tumor to cause tumor regression.

Availability: In stock

Package Price Qty
5 mg
$80.00
25 mg
$260.00
50 mg
$450.00
100 mg
$700.00
10mM * 1mL in DMSO
$104.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Zhang X, .et al. Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist, ACS Infect Dis, 2019, May 14 PMID: 31060350
  • Bowei Liu, .et al. A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists, Antiviral Res, 2017, Nov; 147: 37-46 PMID: 28982551
  • Fang Guo, .et al. Activation of Stimulator of Interferon Genes in Hepatocytes Suppresses the Replication of Hepatitis B Virus, Antimicrob Agents Chemother, 2017, Oct; 61(10): e00771-17 PMID: 28717041

Biological Activity

DMXAA (ASA404) is a tumor-vascular disrupting agent (tumor-VDA) that attacks the blood supply of a cancerous tumor to cause tumor regression.
Targets
DT-diaphorase (Cell-free assay) DT-diaphorase (Cell-free assay)
20 μM(Ki)20 μM(Ki)
In vitro DMSO 7 mg/mL (24.79 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.42 mL 177.12 mL 354.23 mL
0.5 mM 7.08 mL 35.42 mL 70.85 mL
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL

*The above data is based on the productmolecular weight 282.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10324
CAS No. 117570-53-3
Formula C17H14O4
M. Wt 282.3
Purity >98%
Synonyms AS-1404, 5,6-MeXAA, NSC-640488, Vadimezan
SMILES CC1=C(C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(=O)O)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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