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- Zhang X, .et al. Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist, ACS Infect Dis, 2019, May 14 PMID: 31060350
- Bowei Liu, .et al. A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists, Antiviral Res, 2017, Nov; 147: 37-46 PMID: 28982551
- Fang Guo, .et al. Activation of Stimulator of Interferon Genes in Hepatocytes Suppresses the Replication of Hepatitis B Virus, Antimicrob Agents Chemother, 2017, Oct; 61(10): e00771-17 PMID: 28717041
Biological Activity
DMXAA (ASA404) is a tumor-vascular disrupting agent (tumor-VDA) that attacks the blood supply of a cancerous tumor to cause tumor regression.
Targets
| DT-diaphorase (Cell-free assay) | DT-diaphorase (Cell-free assay) | |||
| 20 μM(Ki) | 20 μM(Ki) |
| In vitro | DMSO | 7 mg/mL (24.79 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.42 mL | 177.12 mL | 354.23 mL |
| 0.5 mM | 7.08 mL | 35.42 mL | 70.85 mL |
| 1 mM | 3.54 mL | 17.71 mL | 35.42 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
*The above data is based on the productmolecular weight 282.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10324 |
|---|---|
| CAS No. | 117570-53-3 |
| Formula | C17H14O4 |
| M. Wt | 282.3 |
| Purity | >98% |
| Synonyms | AS-1404, 5,6-MeXAA, NSC-640488, Vadimezan |
| SMILES | CC1=C(C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(=O)O)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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