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Catalog No.
Product Name
Application
Product Information
Product Citation
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DNMT inhibitor
Azacitidine is a chemical analogue of the cytosine nucleoside used in DNA and RNA that is mainly used in the treatment of myelodysplastic syndrome (MDS). -
DNA Methyltransferase Inhibitors
Decitabine is a hypomethylating agent.It hypomethylates DNA by inhibiting DNA methyltransferase.- Tianxing Ying, .et al. , Cancers (Basel), 2022, Dec 30;15(1):243 PMID: 36612238
- Borbala Szabo, .et al. , J Clin Endocrinol Metab, 2022, Sep 5;dgac496 PMID: 36059148
- Sangni Qian, .et al. , Clin Epigenetics, 2022, Sep 5;14(1):111 PMID: 36064442
- Borbála Szabó, .et al. , J Clin Endocrinol Metab, 2020, Jun 1;105(6):dgaa156 PMID: 32232382
- Bracha Shraibman, .et al. , Mol Cell Proteomics, 2016, Sep; 15(9): 3058-3070 PMID: 27412690
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MGMT inhibitor
O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. -
DNA methyltransferase inhibitor
Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor. -
DNMT inhibitor
SGI-110 is a second generation DNA-hypomethyating agent.- Sho Sato, .et al. , Sci Rep, 2023, Jan 27;13(1):1537 PMID: 36707610
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MGMT inhibitor
Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase. -
MGMT inhibitor
O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. -
Sodium channel blocker/DNMT inhibitor
Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor.
