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$0.00 - Daniël Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343
Biological Activity
Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM
Targets
| Factor Xa | Thrombin | FIXa | ||
| 0.561 nM(Ki) | 6 μM(Ki) | 41.7 μM(Ki) |
| In vitro | DMSO | 100 mg/mL (135.45 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.55 mL | 67.73 mL | 135.45 mL |
| 0.5 mM | 2.71 mL | 13.55 mL | 27.09 mL |
| 1 mM | 1.35 mL | 6.77 mL | 13.55 mL |
| 5 mM | 0.27 mL | 1.35 mL | 2.71 mL |
*The above data is based on the productmolecular weight 738.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14317 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 738.27 |
| Formula | C24H30ClN7O4S.C7H8O3S.H2O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1229194-11-9 |
| Synonyms | DU-176b |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCC2=C(C1)SC(=N2)C(=O)N[[email protected]@H]3C[[email protected]](CC[[email protected]@H]3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C.O |
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