Elvitegravir (GS-9137)

Catalog No.: A10347

HIV integrase inhibitor

Elvitegravir (GS-9137)

Elvitegravir (GS-9137) Chemical Structure

CAS NO. 697761-98-1

Elvitegravir (GS-9137) is a potent inhibitor of the strand-transfer step of integration mediated by human immunodeficiency virus type 1 (HIV-1) integrase.

Availability: In stock

Package Price Qty
10 mg
$60.00
50 mg
$280.00
100 mg
$520.00
10mM * 1mL in DMSO
$86.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1
  • El Khoury L, .et al. The inhibition process of HIV-1 integrase by diketoacids molecules: Understanding the factors governing the better efficiency of dolutegravir, Biochem Biophys Res Commun, 2017, Jul 1;488(3):433-438 PMID: 28478035

Biological Activity

Elvitegravir (GS-9137) is a potent inhibitor of the strand-transfer step of integration mediated by human immunodeficiency virus type 1 (HIV-1) integrase.
Targets
HIV-1 IIIB (Cell-free assay) HIV-2 ROD (Cell-free assay) HIV-2 EHO (Cell-free assay)
0.7 nM1.4 nM2.8 nM
In vitro DMSO 85 mg/mL (189.78 mM)
Water Insoluble
Ethanol 33 mg/mL (73.67 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.33 mL 111.63 mL 223.26 mL
0.5 mM 4.47 mL 22.33 mL 44.65 mL
1 mM 2.23 mL 11.16 mL 22.33 mL
5 mM 0.45 mL 2.23 mL 4.47 mL

*The above data is based on the productmolecular weight 447.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10347
Actions Inhibitor
CAS No. 697761-98-1
Formula C23H23ClFNO5
M. Wt 447.9
Purity >98%
Synonyms GS9137
SMILES CC(C)[[email protected]@H](CO)N1C=C(C(=O)C2=CC(=C(C=C21)OC)CC3=C(C(=CC=C3)Cl)F)C(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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