JAK

Catalog No.Inhibitor Name JAK1JAK2JAK3Tyk2Other
A11041Ruxolitinib
***
****
A10241Tofacitinib Citrate
**
**
****
ROCK2,LCK
A10110AZD1480
****
A11082Fedratinib
****
FLT3,RET
A10095AT9283
****
****
***
Aurora B,Aurora A,Abl1
A10047AG-490
*
EGFR,ErbB2
A10263Momelotinib
***
***
*
A11795WP1066
*
STAT3
A11180TG101209
***
*
RET,FLT3
A10546Gandotinib
**
****
**
**
FLT3,FLT4,FGFR2
A11193NVP-BSK805 2HCl
**
****
***
***
A11329Baricitinib
***
***
**
A10104AZ 960
****
A12808CEP-33779
****
A12694Pacritinib
*
**
*
**
FLT3 (D835Y),FLT3
A14049WHI-P154
*
EGFR,Src,VEGFR
A12394XL019
*
****
*
*
PDGFRβ,FLT3,c-Kit
A14955S-Ruxolitinib
***
****
*
**
A13509ZM 39923 HCl
*
**
TGM2,EGFR
A14012Decernotinib
***
***
****
***
A14210Cerdulatinib
***
***
***
****
ARK5,MST1,Fms
A14232Filgotinib
***
**
*
*
A15911FLLL32
*
A11241BMS-911543
*
****
**
**
A14438Peficitinib
A13162GLPG0634 analogue
A12419Go6976
FLT3,PKCα,PKCβ1
A10247Curcumol
A11608WHI-P97
A13082PF-03394197 (oclacitinib)
***
***
**
**
A13457Pyridone 6 (JAK Inhibitor I)
***
****
****
A14132NSC 42834(JAK2 Inhibitor V, Z3)
A14390INCB39110 (Itacitinib)
A14405Solcitinib (GSK2586184)
A15134JANEX-1
*
A15362Cercosporamide
***
Mnk2, Mnk1
A15365TCS 21311
*
*
***
*
A15366ZM 449829
****
****
STAT-5, EGFR, CDK4
A15389NSC 33994
A16227ZM 39923
****
***
TGM2, EGFR

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. ZM39923

    Catalog No. A16227
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    JAK1/3 inhibitor
    ZM39923 is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase. Learn More
  2. Cercosporamide

    Catalog No. A15362
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    Mnk2/JAK3 inhibitor
    Cercosporamide, an usnic amide, was originally identified in Cercosporidium henningsii as a host-selective phytotoxin and broad-spectrum antifungal agent and is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2; IC50 = 11 nM), JAK3 (IC50 = 31), and Mnk1 (IC50 = 116 nM). Learn More
  3. 1,2,3,4,5,6-Hexabromocyclohexane

    Catalog No. A15361
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    JAK2 inhibitor
    1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation. Learn More
  4. JANEX-1

    Catalog No. A15134
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    JAK3 inhibitor
    Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 78 uM); has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. Learn More
  5. CYT387 sulfate salt

    Catalog No. A15056
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    JAK inhibitor
    CYT387 sulfate salt is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Learn More
  6. S-Ruxolitinib

    Catalog No. A14955
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    JAK inhibitor
    S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor. Learn More
  7. ZM 39923 HCl

    Catalog No. A13509
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    JAK3 inhibitor
    ZM 39923 HCl is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 M, respectively) Learn More
  8. Decernotinib

    Catalog No. A14012
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    JAK3 inhibitor
    Decernotinib is an oral, selective Janus kinase 3 (JAK3) inhibitor being developed by Vertex. Learn More
  9. Solcitinib (GSK2586184)

    Catalog No. A14405
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    JAK1 inhibitor
    Solcitinib is a Janus kinase 1 (JAK1) inhibitor. Learn More
  10. INCB39110 (Itacitinib)

    Catalog No. A14390
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    JAK1 Inhibitor
    INCB39110 is a potent JAK1 tyrosine kinase inhibitor, which is currently in Phase II trials for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis. Learn More
  11. Filgotinib

    Catalog No. A14232
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    JAK inhibitor
    Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Learn More
  12. Cucurbitacin I

    Catalog No. A15363
    JAK2/STAT3 inhibitor
    Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells. Learn More
  13. SD 1008

    Catalog No. A15364
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    JAK2/STAT3 inhibitor
    SD 1008 is reported to be a JAK2/STAT3 signaling pathway inhibitor which additionally inhibits Src. SD 1008 is noted to induce apoptosis in cell lines that express constitutively active tyrosine-phosphorylated STAT3. Learn More
  14. NS-018 maleate

    Catalog No. A16226
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    JAK2 inhibitor
    NS-018 maleate is an ATP-competitive small-molecule inhibitor of JAK2 with IC50 of 470nM in Ba/F3-JAK2V617F cells . have30-50-fold greater selectivity for JAK2 over other JAK-family kinases, such as JAK1, JAK3 and tyrosine kinase 2. Learn More
  15. NS-018 hydrochloride

    Catalog No. A16225
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    JAK2 inhibitor
    NS-018 hydrochloride is a novel highly selective JAK2 inhibitor. Learn More
  16. NS-018

    Catalog No. A16224
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    JAK2 inhibitor
    NS-018 is an orally bioavailable, small molecule inhibitor of Janus-associated kinase 2 (JAK2) and Src-family kinases, with potential antineoplastic activity. Learn More
  17. WHI-P97

    Catalog No. A11608
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    JAK3 inhibitor
    WHI-P97 is a rationally designed potent inhibitor of JAK-3. Learn More
  18. FLLL32

    Catalog No. A15911
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    JAK2 inhibitor
    FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 uM. Learn More
  19. Peficitinib (ASP015K, JNJ-54781532)

    Catalog No. A14438
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    JAK inhibitor‎
    Peficitinib is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats. Learn More
  20. Baricitinib phosphate

    Catalog No. A15014
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    JAK inhibitor
    Baricitinib phosphate is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Learn More
  21. NSC 33994

    Catalog No. A15389
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    JAK2 inhibitor
    NSC 33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies. Learn More
  22. ZM 449829

    Catalog No. A15366
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    JAK/STAT inhibitor
    JAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. Learn More
  23. TCS 21311

    Catalog No. A15365
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    JAK3 inhibitor
    TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively). Learn More
  24. Cerdulatinib

    Catalog No. A14210
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    multi-targeted tyrosine kinase inhibitor
    Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Learn More
  25. NSC 42834(JAK2 Inhibitor V, Z3)

    Catalog No. A14132
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    JAK2 inhibitor
    Z3 is a novel specific inhibitor of Jak2 tyrosine kinase. Learn More
  26. PRT 062070 (Cerdulatinib)

    Catalog No. A14147
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    Dual Syk and JAK inhibitor
    PRT062070 is a novel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. Learn More
  27. AZ-960

    Catalog No. A10104
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    JAK2inhibitor
    AZ-960 is a potent, selective and ATP competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45 nM in vitro and induces growth arrest and apoptosis in adult T-cell leukemia (ATL) cell. Learn More
  28. TG-101348 (Fedratinib, SAR302503)

    Catalog No. A11082
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    JAK2 inhibitor
    TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity. Learn More
  29. Curcumol

    Catalog No. A10247
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    JAK2 inhibitor
    Curcumol induces apoptosis via caspases-independent mitochondrial pathway in human lung adenocarcinoma ASTC-a-1 cells. Learn More
  30. Cyt387 (Momelotinib)

    Catalog No. A10263
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    JAK inhibitor
    CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. Learn More
  31. CP-690550 (Tofacitinib citrate)

    Catalog No. A10241
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    JAK3 inhibitor
    CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes. Learn More
  32. AG-490

    Catalog No. A10047
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    EGFR inhibitor
    AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src. Learn More
  33. LY2784544 (Gandotinib)

    Catalog No. A10546
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    JAK inhibitor
    LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders. Learn More
  34. AT9283

    Catalog No. A10095
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    Aurora/JAK inhibitor
    AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation. Learn More
  35. AZD1480

    Catalog No. A10110
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    JAK Inhibitor
    AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. Learn More
  36. INCB018424 (Ruxolitinib)

    Catalog No. A11041
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    JAK1/2 Inhibitor
    INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; Learn More
  37. TG101209

    Catalog No. A11180
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    JAK2 inhibitor

    TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

    Learn More
  38. NVP-BSK805

    Catalog No. A11193
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    JAK inhibitor

    NVP-BSK805 is a potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor that potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.

    Learn More
  39. Baricitinib (LY3009104)

    Catalog No. A11329
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    JAK Inhibitor
    Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). Learn More
  40. WHI-P 154

    Catalog No. A14049
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    JAK3 inhibitor
    WHI-P 154 is a JAK3 inhibitor with IC50 = 1.8uM. WHI-P 154 also Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. Learn More
  41. Pyridone 6 (JAK Inhibitor I)

    Catalog No. A13457
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    JAK inhibitor
    JAK Inhibitor I is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1, JAK2, and JAK3. Learn More
  42. GLPG0634

    Catalog No. A13162
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    JAK1 inhibitor
    GLPG0634 is an orally-available, selective inhibitor of JAK1 (Janus kinase 1) being developed by Galapagos for the treatment of rheumatoid arthritis and potentially other inflammatory diseases. Learn More
  43. PF-03394197 (oclacitinib)

    Catalog No. A13082
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    JAK1 inhibitor
    PF-03394197 (oclacitinib) is a potent JAK1 inhibitor Learn More
  44. XL019

    Catalog No. A12394
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    JAK2 inhibitor
    XL019 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. Learn More
  45. CEP33779

    Catalog No. A12808
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    JAK2 Inhibitor
    CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM. Learn More
  46. Pacritinib (SB1518)

    Catalog No. A12694
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    JAK2/FLT3 inhibitor
    Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis. Learn More
  47. Go 6976

    Catalog No. A12419
    PKC inhibitor
    Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3. Learn More
  48. BMS-911543

    Catalog No. A11241
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    JAK inhibitor
    BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. Learn More
  49. WP1066

    Catalog No. A11795
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    JAK Inhibitor
    WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation. Learn More
  50. Ruxolitinib Phosphate

    Catalog No. A11552
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    JAK inhibitor
    Ruxolitinib Phosphate is the phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Learn More

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