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Biological Activity
Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.
Targets
| Tubulin | ||||
| 2 μM(EC0.01) |
| In vitro | DMSO | 92 mg/mL (186.36 mM) | |
| Water | Insoluble | ||
| Ethanol | 92 mg/mL (186.36 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.26 mL | 101.28 mL | 202.55 mL |
| 0.5 mM | 4.05 mL | 20.26 mL | 40.51 mL |
| 1 mM | 2.03 mL | 10.13 mL | 20.26 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.05 mL |
*The above data is based on the productmolecular weight 493.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10359 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 152044-53-6 |
| Formula | C26H39NO6S |
| M. Wt | 493.7 |
| Purity | >98% |
| Synonyms | EpoA, Epothilone-A |
| SMILES | C[[email protected]]1CCC[[email protected]@H]2[[email protected]@H](O2)C[[email protected]](OC(=O)C[[email protected]@H](C(C(=O)[[email protected]@H]([[email protected]]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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