Total item
Cart Subtotal
$0.00 - Chen JC, .et al. In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells, Biomolecules, 2019, Sep 9;9(9) PMID: 31505885
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
Biological Activity
Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.
Targets
| Topo II (Cell-free assay) | ||||
| In vitro (25°C) | DMSO | 99 mg/mL (168.2 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+40% PEG 300+5% Tween 80+ddH2O | 14 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.99 mL | 84.95 mL | 169.89 mL |
| 0.5 mM | 3.4 mL | 16.99 mL | 33.98 mL |
| 1 mM | 1.7 mL | 8.49 mL | 16.99 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
*The above data is based on the productmolecular weight 588.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10373 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 33419-42-0 |
| Formula | C29H32O13 |
| M. Wt | 588.6 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | VP16, Vepesid, etoposide phosphate |
| SMILES | C[[email protected]@H]1OC[[email protected]@H]2[[email protected]@H](O1)[[email protected]@H]([[email protected]]([[email protected]@H](O2)O[[email protected]]3[[email protected]]4COC(=O)[[email protected]@H]4[[email protected]@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy Etoposide (VP-16) | Etoposide (VP-16) Supplier | purchase | cost | manufacturer | order | distributor | buy 33419-42-0| 33419-42-0 Supplier | purchase 33419-42-0 | 33419-42-0 cost | 33419-42-0 manufacturer | order 33419-42-0 | 33419-42-0 distributor
Adooq Quality Guarantee
We promise all products perform as described.