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- Takashi Azuma,et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Calhelha RC,et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 28991301
|Storage||at -20°C 3 years Powder|
|Synonyms||VP16, Vepesid, etoposide phosphate|
|SMILES code||C[[email protected]@H]1OC[[email protected]@H]2[[email protected]@H](O1)[[email protected]@H]([[email protected]]([[email protected]@H](O2)O[[email protected]]3[[email protected]]4COC(=O)[[email protected]@H]4[[email protected]@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O|
|Chemical Name||4'-demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside], 4' -(dihydrogen phosphate)|
|Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.|
|Solubility (25°C) *||In vitro||DMSO||100 mg/mL (169.9 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||30% propylene glycol, 5% Tween 80, 65% D5W||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||16.99 mL||84.95 mL||169.89mL|
|0.5 mM||3.4 mL||16.99 mL||33.98 mL|
|1 mM||1.7 mL||8.49 mL||16.99 mL|
|5 mM||0.34 mL||1.7 mL||3.4 mL|
*The above data is based on the productmolecular weight 588.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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