Etoposide (VP-16)

Catalog No.: A10373

Topoisomerase II inhibitor

Etoposide (VP-16)

Etoposide (VP-16) Chemical Structure

CAS NO. 33419-42-0

Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.

Availability: In stock

Package Price Qty
100 mg

Regular Price: $50.00

Special Price $45.00

500 mg

Regular Price: $150.00

Special Price $135.00

10mM * 1mL in DMSO

Regular Price: $65.00

Special Price $58.50

Warning WARNING: Attention California Residents: This product can expose you to chemicals including Adriamycin, which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.
Targets
Topo II (Cell-free assay)
In vitro (25°C) DMSO 100 mg/mL (169.9 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.99 mL 84.95 mL 169.89 mL
0.5 mM 3.4 mL 16.99 mL 33.98 mL
1 mM 1.7 mL 8.49 mL 16.99 mL
5 mM 0.34 mL 1.7 mL 3.4 mL

*The above data is based on the productmolecular weight 588.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10373
Actions Inhibitor
M. Wt 588.6
Formula C29H32O13
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 33419-42-0
Synonyms VP16, Vepesid, etoposide phosphate
SMILES C[[email protected]@H]1OC[[email protected]@H]2[[email protected]@H](O1)[[email protected]@H]([[email protected]]([[email protected]@H](O2)O[[email protected]]3[[email protected]]4COC(=O)[[email protected]@H]4[[email protected]@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O

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