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- Fu-Xing Gong, .et al. De-dimerization of PTB is catalyzed by PDI and is involved in the regulation of p53 translation, Nucleic Acids Res, 2021, Sep 20;49(16):9342-9352 PMID: 34403458
Biological Activity
ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
Targets
| mTOR | ATR | DNA-PK | PI3Kα | ATM |
| 0.6 nM | 14 nM | 36 nM | 170 nM | 545 nM |
| In vitro | DMSO | 6 mg/mL (12.75 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.25 mL | 106.27 mL | 212.53 mL |
| 0.5 mM | 4.25 mL | 21.25 mL | 42.51 mL |
| 1 mM | 2.13 mL | 10.63 mL | 21.25 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.25 mL |
*The above data is based on the productmolecular weight 470.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13328 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1345675-02-6 |
| Formula | C30H22N4O2 |
| M. Wt | 470.52 |
| Purity | >98% |
| Synonyms | ETP46464, ETP 46464 |
| SMILES | CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3COC2=O)C5=CC6=CC=CC=C6N=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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