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Catalog No.: A13328

ATR inhibitor


ETP-46464 Chemical Structure

CAS NO. 1345675-02-6

ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Fu-Xing Gong, .et al. De-dimerization of PTB is catalyzed by PDI and is involved in the regulation of p53 translation, Nucleic Acids Res, 2021, Sep 20;49(16):9342-9352 PMID: 34403458

Biological Activity

ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
0.6 nM14 nM36 nM170 nM545 nM
In vitro DMSO 6 mg/mL (12.75 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.25 mL 106.27 mL 212.53 mL
0.5 mM 4.25 mL 21.25 mL 42.51 mL
1 mM 2.13 mL 10.63 mL 21.25 mL
5 mM 0.43 mL 2.13 mL 4.25 mL

*The above data is based on the productmolecular weight 470.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13328
Actions Inhibitor
CAS No. 1345675-02-6
Formula C30H22N4O2
M. Wt 470.52
Purity >98%
Synonyms ETP46464, ETP 46464

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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