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Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.81 mL | 94.06 mL | 188.11 mL |
| 0.5 mM | 3.76 mL | 18.81 mL | 37.62 mL |
| 1 mM | 1.88 mL | 9.41 mL | 18.81 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.76 mL |
*The above data is based on the productmolecular weight 531.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11231 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 531.6 |
| Formula | C25H26FN3O7S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 171335-80-1 |
| Synonyms | DX 8951, DX8951 |
| SMILES | CC[[email protected]@]1(C2=C(COC1=O)C(=O)N3CC4=C5[[email protected]](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N)O |
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