FMK

Catalog No.: A11423

RSK inhibitor

FMK

FMK Chemical Structure

CAS NO. 821794-92-7

FMK is potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. Fmk induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells.

Availability: In stock

Package Price Qty
5 mg
$180.00
10 mg
$320.00
25 mg
$640.00
50 mg
$1,100.00
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Biological Activity

FMK is potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. Fmk induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.21 mL 146.04 mL 292.08 mL
0.5 mM 5.84 mL 29.21 mL 58.42 mL
1 mM 2.92 mL 14.6 mL 29.21 mL
5 mM 0.58 mL 2.92 mL 5.84 mL

*The above data is based on the productmolecular weight 342.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11423
Actions Inhibitor
CAS No. 821794-92-7
Formula C18H19FN4O2
M. Wt 342.37
Solubility DMSO
Purity >98%
SMILES CC1=CC=C(C=C1)C2=C(N(C3=C2C(=NC=N3)N)CCCO)C(=O)CF
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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