γ-Secretase

Catalog No.Inhibitor Name γ secretaseNotchOther
A10288DAPT (GSI-IX)
*
A10802RO4929097
***
***
Aβ40
A10836Semagacestat
**
**
A10157Avagacestat
****
A11174Dibenzazepine
***
***
A11176LY411575
****
****
A15899L-685458
*
A13815FLI-06
*
A13319PF-03084014
**
A11194MK-0752
***
Aβ40
A13544LY3039478
****
A16152IMR-1
*
A16223IMR-1A
*
A11258Begacestat (GSI-953)
**
A12444BMS 299897
A13217TC-E 5006
*
A15304MRK 560
****
A15301JLK 6
A16214CHF5074
*
A16215Z-Ile-Leu-aldehyde

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Compound W

    Catalog No. A15296
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    Gamma-secretase modulator
    Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25. Learn More
  2. JLK 6

    Catalog No. A15301
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    γ-secretase inhibitor
    JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways. Learn More
  3. MRK 560

    Catalog No. A15304
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    γ-secretase inhibitor
    MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo. Learn More
  4. PF-03084014

    Catalog No. A11259
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    γ-secretase inhibitor
    PF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM . Learn More
  5. Flurbiprofen Axetil

    Catalog No. A13662
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    gamma-secretase inhibitor
    Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID). Learn More
  6. L-685458

    Catalog No. A15899
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    γ-secretase inhibitor
    L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. Learn More
  7. Begacestat (GSI-953)

    Catalog No. A11258
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    γ-secretase inhibitor
    Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. Learn More
  8. gamma-secretase modulator 1

    Catalog No. A11425
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    Gamma-secretase modulator
    gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease. Learn More
  9. gamma-secretase modulator 2

    Catalog No. A11427
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    Gamma-secretase modulator
    gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease. Learn More
  10. TC-E 5006

    Catalog No. A13217
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    Gamma-secretase modulator
    TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Learn More
  11. CHF5074

    Catalog No. A16214
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    γ-Secretase modulator
    CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively. Learn More
  12. Z-Ile-Leu-aldehyde

    Catalog No. A16215
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    γ-Secretase inhibitor
    Z-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor. Learn More
  13. gamma-secretase modulator 3

    Catalog No. A15090
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    gamma-secretase modulator
    gamma-secretase modulator 3 is a gamma-secretase modulator. Learn More
  14. LY-900009

    Catalog No. A14088
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    Notch inhibitor
    LY-900009 is a potent inhibitor of Notch with IC50 value of 0.27 nM. Learn More
  15. IMR-1

    Catalog No. A16152
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    Notch inhibitor
    IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L. Learn More
  16. RO4929097

    Catalog No. A10802
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    Gamma-secretase inhibitor
    RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. Learn More
  17. LY3039478

    Catalog No. A13544
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    Notch inhibitor
    LY3039478 is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. Learn More
  18. BMS-708163 (Avagacestat)

    Catalog No. A10157
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    Gamma-secretase inhibitor
    BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis. Learn More
  19. MK-0752

    Catalog No. A11194
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    Gamma-secretase inhibitor
    MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. Learn More
  20. DAPT (GSI-IX)

    Catalog No. A10288
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    Gamma secretase inhibitor
    DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. Learn More
  21. YO-01027

    Catalog No. A11174
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    γ-secretase inhibitor
    YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent. Learn More
  22. LY-411575

    Catalog No. A11176
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    Gamma secretase inhibitor

    LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

    Learn More
  23. Semagacestat (LY450139)

    Catalog No. A10836
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    Gamma-secretase inhibitor
    Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM. Learn More
  24. LY2811376

    Catalog No. A11776
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    BACE1 inhibitor
    LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals. Learn More
  25. BMS 433796

    Catalog No. A11337
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    γ-Secretase Inhibitor
    BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease. Learn More
  26. E 2012

    Catalog No. A11393
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    gamma-secretase modulator
    E 2012 is γ-secretase inhibitor. Learn More
  27. BMS 299897

    Catalog No. A12444
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    γ-secretase inhibitor
    BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Learn More
  28. Flurizan

    Catalog No. A12433
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    gamma-secretase modulator
    Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Learn More
  29. FLI-06

    Catalog No. A13815
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    Gamma-secretase inhibitor
    FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. Learn More
  30. IMR-1A

    Catalog No. A16223
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    Notch inhibitor
    IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L. Learn More

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