GSK-3

Catalog No.Inhibitor Name GSK-3 GSK-3α GSK-3β Other Targets
A10825SB216763
**
**
A11085CHIR-98014
****
****
Cdc2
A11223TWS119
**
A11592Tideglusib
*
A11061SB415286
*
*
A10199CHIR-99021
***
****
A13060AZD2858
*
A12819AZD1080
***
**
A13728AR-A014418
**
A11941TDZD-8
*
A12741LY2090314
****
****
A15555BIO-acetoxime
***
***
A14196IM-12
**
A10471Indirubin
*
CDK2/CyclinA,CDK5/p35,CDK1/CyclinB
A15526Bikinin
A143031-Azakenpaullone
A16280Indirubin-3-monoxime
***
CDK1/5
A16230CP21R7

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. CHIR-99021

    Catalog No. A10199
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    GSK-3 Inhibitor
    CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. Learn More
  2. Bikinin

    Catalog No. A15526
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    GSK-3 inhibitor
    Bikinin is a potent inhibitor of plant GSK-3/Shaggy-like kinase; activates BR signaling downstream of the BR receptor. Learn More
  3. IM-12

    Catalog No. A14196
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    GSK-3β inhibitor
    IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. Learn More
  4. 1-Azakenpaullone

    Catalog No. A14303
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    GSK-3β inhibitor
    1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. Learn More
  5. AR-A 014418

    Catalog No. A13728
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    GSK-3 inhibitor
    AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Learn More
  6. AZD2858

    Catalog No. A13060
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    GSK-3β inhibitor
    AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats. Learn More
  7. AZD1080

    Catalog No. A12819
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    GSK3 inhibitor
    AZD1080 is a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. Learn More
  8. LY2090314

    Catalog No. A12741
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    GSK-3 inhibitor
    LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis. Learn More
  9. Tideglusib

    Catalog No. A11592
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    GSK-3 Inhibitor
    Tideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy Learn More
  10. Indirubin

    Catalog No. A10471
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    CDK & GSK-3β inhibitor
    Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. Learn More
  11. SB 216763

    Catalog No. A10825
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    GSK-3 inhibitor
    SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β). Learn More
  12. SB 415286

    Catalog No. A11061
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    GSK-3 inhibitor
    SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. Learn More
  13. CHIR-98014

    Catalog No. A11085
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    GSK-3 inhibitor
    CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3. Learn More
  14. TWS119

    Catalog No. A11223
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    GSK-3 Inhibitor
    TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM. Learn More
  15. TDZD-8

    Catalog No. A11941
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    GSK-3 Inhibitor
    TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity Learn More
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    BIO

    Catalog No. A17129
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    GSK3 inhibitor
    BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β with IC50 value of 5 nM. Learn More
  16. BIO-acetoxime

    Catalog No. A15555
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    GSK-3 inhibitor
  17. GSK-3b

    Catalog No. A15471
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    GSK-3 beta Inhibitor
  18. CP21R7

    Catalog No. A16230
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    GSK-3β inhibitor
    CP21R7 is a potent and selective GSK-3β inhibitor. Learn More
  19. Indirubin-3-monoxime

    Catalog No. A16280
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    GSK-3β inhibitor
    Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM). Learn More

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