GSK429286A

Catalog No.: A10441

ROCK Inhibitor

GSK429286A

GSK429286A Chemical Structure

CAS NO. 864082-47-3

GSK429286A is a cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $80.00

Special Price $72.00

25 mg

Regular Price: $208.00

Special Price $187.20

50 mg

Regular Price: $360.00

Special Price $324.00

100 mg

Regular Price: $580.00

Special Price $522.00

10mM * 1mL in DMSO

Regular Price: $80.00

Special Price $72.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK429286A is a cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK).
Targets
ROCK1 ROCK2
14 nM63 nM
In vitro (25°C) DMSO 87 mg/mL (201.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (9.25 mM)
In vivo 15% Captisol/citrate vehicle 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.13 mL 115.63 mL 231.27 mL
0.5 mM 4.63 mL 23.13 mL 46.25 mL
1 mM 2.31 mL 11.56 mL 23.13 mL
5 mM 0.46 mL 2.31 mL 4.63 mL

*The above data is based on the productmolecular weight 432.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10441
Actions Inhibitor
M. Wt 432.4
Formula C21H16F4N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 864082-47-3
Synonyms GSK-429286A
SMILES CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F

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