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Catalog No.
Product Name
Application
Product Information
Product Citation
Hedgehog signaling inhibitor
Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor.
Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.
JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).
SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway.
RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM.
Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor.
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2.
cholesterol synthesis/Hedgehog inhibitor
U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor.
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