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Hesperetin

Catalog No.: A10449

PDE4 inhibitor

Hesperetin

Hesperetin Chemical Structure

CAS NO. 520-33-2

Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$50.00
50 mg
$60.00
100 mg
$80.00
10mM * 1mL in DMSO
$50.00
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Biological Activity

Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer.
Targets
Histamine receptor TGF-β
In vitro DMSO 58 mg/mL (191.87 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.08 mL 165.4 mL 330.8 mL
0.5 mM 6.62 mL 33.08 mL 66.16 mL
1 mM 3.31 mL 16.54 mL 33.08 mL
5 mM 0.66 mL 3.31 mL 6.62 mL

*The above data is based on the productmolecular weight 302.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10449
Actions Inhibitor
CAS No. 520-33-2
Formula C16H14O6
M. Wt 302.3
Purity >98%
SMILES COC1=C(C=C(C=C1)[[email protected]@H]2CC(=O)C3=C(C=C(C=C3O2)O)O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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