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Biological Activity
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer.
Targets
| Histamine receptor | TGF-β | |||
| In vitro | DMSO | 58 mg/mL (191.87 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.08 mL | 165.4 mL | 330.8 mL |
| 0.5 mM | 6.62 mL | 33.08 mL | 66.16 mL |
| 1 mM | 3.31 mL | 16.54 mL | 33.08 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.62 mL |
*The above data is based on the productmolecular weight 302.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10449 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 520-33-2 |
| Formula | C16H14O6 |
| M. Wt | 302.3 |
| Purity | >98% |
| SMILES | COC1=C(C=C(C=C1)[[email protected]@H]2CC(=O)C3=C(C=C(C=C3O2)O)O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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