Histone Acetyltransferases

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  1. GNE-207

    Catalog No. A18844
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    CBP bromodomain inhibitor
    GNE-207 is a novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP. GNE-207 has excellent CBP potency (CBP IC50?=?1?nM, MYC EC50?=?18?nM), and it exhibits a good pharmacokinetic profile. Learn More
  2. CPI-637

    Catalog No. A16470
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    CBP/EP300 bromodomain inhibitor
    CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor. Learn More
  3. EML 425

    Catalog No. A16180
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    CBP/p300 inhibitor
    EML 425 is a reversible and non-competitive CBP/p300 inhibitor that is cell permeable (IC50 values are 1.1 and 2.9 uM, respectively). Learn More
  4. PRI-724

    Catalog No. A15856
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    CBP/beta-catenin antagonist

    PRI-724, an isomer or enantiomer of ICG-001 (A11039), is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity.

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  5. A-485

    Catalog No. A16830
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    p300/CBP inhibitor
    A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs. Learn More
  6. GNE-049

    Catalog No. A20206
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    CBP inhibitor
    GNE-049 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively. Learn More
  7. TPOP146

    Catalog No. A12655
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    CBP/P300 benzoxazepine bromodomain inhibitor
    TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. Learn More
  8. I-CBP112

    Catalog No. A13165
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    CBP/p300 bromodomain inhibitor
    I-CBP112 is a highly potent and selective p300/CBP bromodomain inhibitor (IC50 ~0.14-0.17 uM for CBP and ~0.625 uM for p300). Learn More
  9. SGC-CBP30

    Catalog No. A13227
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    CBP/p300 bromodomain inhibitor
    SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. Learn More
  10. Histone Acetyltransferase Inhibitor II

    Catalog No. A12331
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    p300 inhibitor
    Histone Acetyltransferase Inhibitor II is a potent and cell permeable p300 inhibitor, with an IC50 of 5µM; Histone Acetyltransferase Inhibitor II can be used in cancer research. Learn More
  11. E-7386

    Catalog No. A17089
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    CBP/beta-catenin modulator
    E-7386 is an orally active CBP/beta-catenin modulator. Learn More
  12. CTPB

    Catalog No. A18558
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    p300 HAT activator
    CTPB is an activator of p300 HAT (histone acetyltransferase) without PCAF (p300/CBP-associated factor) HAT activities. Learn More
  13. P300/CBP-IN-3

    Catalog No. A18544
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    p300/CBP histone acetyltransferase inhibitor
    P300/CBP-IN-3, a p300/CBP histone acetyltransferase inhibitor. Learn More
  14. Remodelin

    Catalog No. A21985
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    acetyl-transferase protein NAT10 inhibitor
    Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. Learn More
  15. Garcinol

    Catalog No. A12814
    HAT inhibitor
    Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50=7µM) and PCAF (IC50=5µM) both in vitro and in vivo. Learn More
  16. WM-1119

    Catalog No. A16828
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    lysine acetyltransferase KAT6A inhibitor
    WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively. Learn More
  17. MG149

    Catalog No. A14267
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    KAT5 (Tip60) HAT inhibitor
    MG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 uM and 47 uM for Tip60 and MOF. Learn More
  18. Remodelin Hydrobromide

    Catalog No. A14215
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    NAT10 inhibitor
    Remodelin Hydrobromide is a potent acetyl-transferase NAT10 inhibitor. Learn More
  19. Anacardic Acid

    Catalog No. A14226
    KAT5 (Tip60), p300/PCAF inhibitor
    Anacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. Learn More
  20. NU 9056

    Catalog No. A13378
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    KAT5 (Tip60) HAT inhibitor
    NU9056 is an selective KAT5 (Tip60) HAT inhibitor. IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively. Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation. Learn More
  21. C646

    Catalog No. A12815
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    p300/CBP inhibitor
    C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM). Learn More
  22. YF-2

    Catalog No. A21018
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    histone acetyltransferase activator
    YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease. Learn More

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