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$0.00 Histone Acetyltransferases
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GNE-207
Catalog No. A18844 CBP bromodomain inhibitorGNE-207 is a novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP. GNE-207 has excellent CBP potency (CBP IC50?=?1?nM, MYC EC50?=?18?nM), and it exhibits a good pharmacokinetic profile. Learn More -
CPI-637
Catalog No. A16470 CBP/EP300 bromodomain inhibitorCPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor. Learn More -
EML 425
Catalog No. A16180 CBP/p300 inhibitorEML 425 is a reversible and non-competitive CBP/p300 inhibitor that is cell permeable (IC50 values are 1.1 and 2.9 uM, respectively). Learn More -
PRI-724
Catalog No. A15856 CBP/beta-catenin antagonistPRI-724, an isomer or enantiomer of ICG-001 (A11039), is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity.
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A-485
Catalog No. A16830 p300/CBP inhibitorA-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs. Learn More -
GNE-049
Catalog No. A20206 CBP inhibitorGNE-049 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively. Learn More -
TPOP146
Catalog No. A12655 CBP/P300 benzoxazepine bromodomain inhibitorTPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. Learn More -
I-CBP112
Catalog No. A13165 CBP/p300 bromodomain inhibitorI-CBP112 is a highly potent and selective p300/CBP bromodomain inhibitor (IC50 ~0.14-0.17 uM for CBP and ~0.625 uM for p300). Learn More -
SGC-CBP30
Catalog No. A13227 CBP/p300 bromodomain inhibitorSGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. Learn More -
Histone Acetyltransferase Inhibitor II
Catalog No. A12331 p300 inhibitorHistone Acetyltransferase Inhibitor II is a potent and cell permeable p300 inhibitor, with an IC50 of 5µM; Histone Acetyltransferase Inhibitor II can be used in cancer research. Learn More -
E-7386
Catalog No. A17089 CBP/beta-catenin modulatorE-7386 is an orally active CBP/beta-catenin modulator. Learn More -
CTPB
Catalog No. A18558 p300 HAT activatorCTPB is an activator of p300 HAT (histone acetyltransferase) without PCAF (p300/CBP-associated factor) HAT activities. Learn More -
P300/CBP-IN-3
Catalog No. A18544 p300/CBP histone acetyltransferase inhibitorP300/CBP-IN-3, a p300/CBP histone acetyltransferase inhibitor. Learn More -
Remodelin
Catalog No. A21985 acetyl-transferase protein NAT10 inhibitorRemodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. Learn More -
Garcinol
Catalog No. A12814 HAT inhibitorGarcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50=7µM) and PCAF (IC50=5µM) both in vitro and in vivo. Learn More -
WM-1119
Catalog No. A16828 lysine acetyltransferase KAT6A inhibitorWM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively. Learn More -
MG149
Catalog No. A14267 KAT5 (Tip60) HAT inhibitorMG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 uM and 47 uM for Tip60 and MOF. Learn More -
Remodelin Hydrobromide
Catalog No. A14215 NAT10 inhibitorRemodelin Hydrobromide is a potent acetyl-transferase NAT10 inhibitor. Learn More -
Anacardic Acid
Catalog No. A14226 KAT5 (Tip60), p300/PCAF inhibitorAnacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. Learn More -
NU 9056
Catalog No. A13378 KAT5 (Tip60) HAT inhibitorNU9056 is an selective KAT5 (Tip60) HAT inhibitor. IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively. Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation. Learn More -
C646
Catalog No. A12815 p300/CBP inhibitorC646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM). Learn More -
YF-2
Catalog No. A21018 histone acetyltransferase activatorYF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease. Learn More
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