β-catenin

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  1. Hexachlorophene

    Catalog No. A16217
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    Wnt/beta-catenin inhibitor
    Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 uM; also is an inhibitor of Wnt/beta-catenin signaling. Learn More
  2. Longdaysin

    Catalog No. A21022
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    Wnt/β-catenin signaling inhibitor
    Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Learn More
  3. SKL2001

    Catalog No. A16707
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    Wnt/β-catenin agonist
    SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction. Learn More
  4. HLY78

    Catalog No. A18402
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    Wnt/β-catenin activator
    HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. Learn More
  5. Wnt/β-catenin agonist 1

    Catalog No. A18689
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    Wnt/β-catenin agonist
    Wnt/β-catenin agonist 1 is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM. Learn More
  6. IWP-4

    Catalog No. A17004
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    Wnt/β-catenin signaling inhibitor
    IWP-4 is a novel potent inhibitor of Wnt/β-catenin signaling. Learn More
  7. iCRT3

    Catalog No. A16847
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    Wnt/β-catenin antagonist
    iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays. Learn More
  8. KYA1797K

    Catalog No. A16353
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    Wnt/beta-catenin inhibitor
    KYA1797K is a highly potent and selective Wnt/beta-catenin inhibitor with IC50 of 0.75 μM (TOPflash assay). Learn More
  9. iCRT 14

    Catalog No. A16218
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    CRT inhibitor
    iCRT 14 is a novel potent inhibitor of beta-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Learn More
  10. ICG-001

    Catalog No. A11039
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    Wnt/beta-catenin inhibitor
    ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) . Learn More
  11. Cardiogenol C HCl

    Catalog No. A16198
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    Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 uM. Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Learn More
  12. IQ-1

    Catalog No. A16064
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    Wnt/beta-catenin inhibitor
    IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/beta-catenin signaling. Learn More
  13. Cardiogenol C hydrochloride

    Catalog No. A15773
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    Cardiogenol C hydrochloride is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm. Learn More
  14. BC2059

    Catalog No. A14381
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    beta-catenin inhibitor
    BC2059 is an orally bioavailable and potent beta-catenin inhibitor. Learn More
  15. WAY-316606

    Catalog No. A13986
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    sFRP-1 inhibitor
    WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Learn More
  16. FH535

    Catalog No. A13795
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  17. IWR-1-endo

    Catalog No. A12737
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    Wnt inhibitor
    IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. Learn More

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