CXCR

Catalog No.Inhibitor Name CXCR1CXCR2CXCR4Other
A10913Plerixafor 8HCl
**
CXCL12-mediated chemotaxis
A13074Plerixafor
**
CXCL12-mediated chemotaxis
A12588WZ811
****
A14209SB225002
***
A16351ATI-2341
*
A14997AMD-070 HCl
***
A15234SCH 563705
****
***
A14209SB225002
***
A11555SCH-527123 (Navarixin)
**
***
A12383Reparixin
****
**
CXCL8
A12596MSX-122
***
A11315AMD 070
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Plerixafor 8HCl (DB06809)

    Catalog No. A10913
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    CXCR4 antagonist
    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More
  2. AMD3100 (Plerixafor)

    Catalog No. A13074
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    CXCR4 antagonist
    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More
  3. USL311

    Catalog No. A18778
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    CXCR4 receptor antagonist
    USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. Learn More
  4. WZ811

    Catalog No. A12588
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    CXCR4 antagonist
    WZ811 is a C-X-C chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM). Learn More
  5. NSC-23026

    Catalog No. A17151
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    CXCR4 receptor modulator
    NSC-23026 is a CXCR4 receptor modulator. Learn More
  6. AMD 070

    Catalog No. A11315
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    CXCR4 antagonist
    AMD 070 is a CXCR4 chemokine receptor antagonist. Learn More
  7. AMD-070 HCl

    Catalog No. A14997
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    CXCR4 antagonist
    AMD-070 hydrochloride is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, inhibit the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. Learn More
  8. MSX-122

    Catalog No. A12596
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    CXCR4 Inhibitor
    MSX-122 is an orally bioavailable inhibitor of CXCR4 (IC50 = ~10 nM) with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration. Learn More
  9. MSX-130

    Catalog No. A17150
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    CXCR4 Antagonist
    MSX-130 is CXCR4 antagonist. Learn More
  10. AMD 3465 Hexahydrobromide

    Catalog No. A11953
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    CXCR4 antagonist
    AMD 3465 is a potent, selective CXCR4 antagonist. Learn More
  11. ATI-2341

    Catalog No. A16351
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    CXCR4 agonist
    ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4) (EC50 = 194 nM, is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. Learn More

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