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CDK & GSK-3β inhibitor

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Catalog No. A10471

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Indirubin 5mg A10471-5

Regular Price: $40.00

Special Price: $36.00

Indirubin 25mg A10471-25

Regular Price: $120.00

Special Price: $108.00

Indirubin 50mg A10471-50

Regular Price: $200.00

Special Price: $180.00

Indirubin 100mg A10471-100

Regular Price: $350.00

Special Price: $315.00

Indirubin 10mM * 1mL in DMSO A10471-10mM-D

Regular Price: $80.00

Special Price: $72.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.


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Chemical Information

Catalog Num A10471
Actions Inhibitor
M. Wt 262.3
Formula C16H10N2O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 479-41-4
Synonyms Couroupitine B, Indigo red
SMILES C1=CC=C2C(=C1)/C(=C\3/C(=O)C4=CC=CC=C4N3)/C(=O)N2

Biological Activity

Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.
Target Value
GSK-3βIC50: 0.6μM
CDK2/CyclinAIC50: 2.2μM
CDK5/p35IC50: 5.5μM
CDK1/CyclinBIC50: 10μM
C-RafIC50: >10μM
CDK4/CyclinD1IC50: 12μM
c-SrcIC50: 18μM
ERK2IC50: 43μM
ERK1IC50: >100μM
MAPKKIC50: >100μM
PKCαIC50: >100μM
PKCβ1IC50: >100μM
PKCβ2IC50: >100μM
PKCγIC50: >100μM
PKCδIC50: >100μM
PKCεIC50: >100μM
PKCηIC50: >100μM
PKCζIC50: >100μM
c-AblIC50: >1000μM


Solubility (25°C)* In vitro DMSO 53 mg/mL (202.08 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.12 mL 190.62 mL 381.24mL
0.5 mM 7.62 mL 38.12 mL 76.25 mL
1 mM 3.81 mL 19.06 mL 38.12 mL
5 mM 0.76 mL 3.81 mL 7.62 mL

*The above data is based on the productmolecular weight 262.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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