Biological Activity
Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.
Targets
Target | Value |
---|---|
GSK-3β | IC50: 0.6μM |
CDK2/CyclinA | IC50: 2.2μM |
CDK5/p35 | IC50: 5.5μM |
CDK1/CyclinB | IC50: 10μM |
C-Raf | IC50: >10μM |
CDK4/CyclinD1 | IC50: 12μM |
c-Src | IC50: 18μM |
ERK2 | IC50: 43μM |
ERK1 | IC50: >100μM |
MAPKK | IC50: >100μM |
PKCα | IC50: >100μM |
PKCβ1 | IC50: >100μM |
PKCβ2 | IC50: >100μM |
PKCγ | IC50: >100μM |
PKCδ | IC50: >100μM |
PKCε | IC50: >100μM |
PKCη | IC50: >100μM |
PKCζ | IC50: >100μM |
c-Abl | IC50: >1000μM |
In vitro | DMSO | 48 mg/mL (183.02 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 38.12 mL | 190.62 mL | 381.24 mL |
0.5 mM | 7.62 mL | 38.12 mL | 76.25 mL |
1 mM | 3.81 mL | 19.06 mL | 38.12 mL |
5 mM | 0.76 mL | 3.81 mL | 7.62 mL |
*The above data is based on the productmolecular weight 262.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10471 |
---|---|
Actions | Inhibitor |
CAS No. | 479-41-4 |
Formula | C16H10N2O2 |
M. Wt | 262.3 |
Solubility | DMSO |
Purity | >98% |
Synonyms | Couroupitine B, Indigo red |
SMILES | C1=CC=C2C(=C1)/C(=C\3/C(=O)C4=CC=CC=C4N3)/C(=O)N2 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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