Indomethacin (Indocid, Indocin)

Catalog No.: A10474

COX inhibitor

Indomethacin (Indocid, Indocin)

Indomethacin (Indocid, Indocin) Chemical Structure

CAS NO. 53-86-1

Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.

Availability: In stock

Package Price Qty
100 mg
$50.00
250 mg
$100.00
500 mg
$180.00
1000 mg
$330.00
10mM * 1mL in DMSO
$61.00
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  • Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
  • Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347

Biological Activity

Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.
Targets
COX1 COX-2
0.28 μM14 μM
In vitro DMSO 72 mg/mL (201.23 mM)
Water <1 mg/mL (<1 mM)
Ethanol 24 mg/mL (67.07 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.95 mL 139.75 mL 279.49 mL
0.5 mM 5.59 mL 27.95 mL 55.9 mL
1 mM 2.79 mL 13.97 mL 27.95 mL
5 mM 0.56 mL 2.79 mL 5.59 mL

*The above data is based on the productmolecular weight 357.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10474
Actions Inhibitor
M. Wt 357.79
Formula C19H16ClNO4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 53-86-1
Synonyms Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin
SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

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