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Indomethacin (Indocid, Indocin)

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COX inhibitor

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Catalog No. A10474

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Indomethacin (Indocid, Indocin) 100mg A10474-100

Regular Price: $50.00

Special Price: $45.00

Indomethacin (Indocid, Indocin) 250mg A10474-250

Regular Price: $100.00

Special Price: $90.00

Indomethacin (Indocid, Indocin) 500mg A10474-500

Regular Price: $180.00

Special Price: $162.00

Indomethacin (Indocid, Indocin) 1000mg A10474-1000

Regular Price: $330.00

Special Price: $297.00

Indomethacin 10mM * 1mL in DMSO A10474-10mM-D

Regular Price: $61.00

Special Price: $54.90

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.

Indomethacin (Indocid, Indocin)

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Publications citing Adooq Products
Indomethacin (Indocid, Indocin) Citations (2)
  • Azuma T,et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 28660504
  • Azuma T,et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 26802347

Chemical Information

Catalog Num A10474
Actions Inhibitor
M. Wt 357.79
Formula C19H16ClNO4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 53-86-1
Synonyms Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin
SMILES code CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
Chemical Name 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid

Biological Activity

Description
Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.
Targets
COX1 COX-2
0.28 μM14 μM

Solubility

Solubility (25°C)* In vitro DMSO 72 mg/mL (201.23 mM)
Water <1 mg/mL (<1 mM)
Ethanol 24 mg/mL (67.07 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.95 mL 139.75 mL 279.49mL
0.5 mM 5.59 mL 27.95 mL 55.9 mL
1 mM 2.79 mL 13.97 mL 27.95 mL
5 mM 0.56 mL 2.79 mL 5.59 mL

*The above data is based on the productmolecular weight 357.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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