Integrase

Catalog No.Inhibitor Name Integrase
A10775Raltegravir (MK-0518)
*
A10347Elvitegravir (GS-9137, JTK-303)
****
A11068Dolutegravir (GSK1349572)
***
A10156BMS-707035
**
A11135MK-2048
***
A16014Cabotegravir (GSK744, GSK1265744)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Raltegravir (MK-0518)

    Catalog No. A10775
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    HIV-1 integrase inhibitor
    Raltegravir (MK-0518) targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV. Learn More
  2. S/GSK1349572 (Dolutegravir)

    Catalog No. A11068
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    HIV integrase inhibitor
    S/GSK1349572 is a potent next generation HIV integrase inhibitor and demonstrates a superior resistance profile substantiated with 60 integrase mutant molecular clones. Learn More
  3. MK-2048

    Catalog No. A11135
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    HIV integrase inhibitor
    MK-2048 is a second generation integrase inhibitor, intended to be used against HIV infection. Learn More
  4. BMS-707035

    Catalog No. A10156
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    HIV-1 integrase inhibitor

    BMS-707035 is an HIV-1 integrase (IN) inhibitor. HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic.

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  5. Elvitegravir (GS-9137)

    Catalog No. A10347
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    HIV integrase inhibitor
    Elvitegravir (GS-9137) is a potent inhibitor of the strand-transfer step of integration mediated by human immunodeficiency virus type 1 (HIV-1) integrase. Learn More
  6. GSK1265744 (GSK744) Sodium salt

    Catalog No. A13984
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    HIV Integrase Inhibitor
    GSK1265744 (GSK744) is a potential inhibitor of HIV integrase with IC50 value of 3 nM Learn More
  7. GSK744 (S/GSK1265744)

    Catalog No. A16014
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    HIV integrase inhibitor
    GSK744 is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. Learn More
  8. BI 224436

    Catalog No. A16018
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    HIV integrase inhibitor
    BI 224436 is a novel HIV-1 non-catalytic-site integrase inhibitor; has antiviral EC50s of <15 nM against different HIV-1 laboratory strains and cellular cytotoxicity of >90 μM. Learn More
  9. Dolutegravir Sodium

    Catalog No. A16162
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    HIV integrase inhibitor
    Dolutegravir sodium is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. Learn More

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