ISRIB (trans-isomer)

Catalog No.: A13816

PERK inhibitor

ISRIB (trans-isomer)

ISRIB (trans-isomer) Chemical Structure

CAS NO.

ISRIB (trans-isomer) is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $90.00

Special Price $81.00

25 mg

Regular Price: $180.00

Special Price $162.00

50 mg

Regular Price: $320.00

Special Price $288.00

100 mg

Regular Price: $520.00

Special Price $468.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ISRIB (trans-isomer) is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.16 mL 110.78 mL 221.56 mL
0.5 mM 4.43 mL 22.16 mL 44.31 mL
1 mM 2.22 mL 11.08 mL 22.16 mL
5 mM 0.44 mL 2.22 mL 4.43 mL

*The above data is based on the productmolecular weight 451.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A13816
Actions Inhibitor
M. Wt 451.34
Formula C22H24Cl2N2O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. No
Synonyms N/A
SMILES O=C(N[[email protected]@H]1CC[[email protected]@H](NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3

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