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ISRIB (trans-isomer)

ISRIB (trans-isomer)

Name: ISRIB (trans-isomer)
SKU: A13816

Catalog No.: A13816

PERK inhibitor

ISRIB (trans-isomer) Chemical Structure

CAS NO.

ISRIB (trans-isomer) is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation.

Availability: In stock

Package	Price	Qty
10 mg	Regular Price: $90.00 Special Price $81.00
25 mg	Regular Price: $180.00 Special Price $162.00
50 mg	Regular Price: $320.00 Special Price $288.00
100 mg	Regular Price: $520.00 Special Price $468.00

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

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Biological Activity

ISRIB (trans-isomer) is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.16 mL	110.78 mL	221.56 mL
0.5 mM	4.43 mL	22.16 mL	44.31 mL
1 mM	2.22 mL	11.08 mL	22.16 mL
5 mM	0.44 mL	2.22 mL	4.43 mL

*The above data is based on the productmolecular weight 451.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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PERK

Chemical Properties

Catalog Num	A13816
Actions	Inhibitor
M. Wt	451.34
Formula	C22H24Cl2N2O4
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	No
Synonyms	N/A
SMILES	O=C(N[[email protected]@H]1CC[[email protected]@H](NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3