JK 184

Catalog No.: A12925

Hedgehog inhibitor

JK 184

JK 184 Chemical Structure

CAS NO. 315703-52-7

JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).

Availability: In stock

Package Price Qty
10 mg
$85.00
25 mg
$200.00
50 mg
$350.00
100 mg
$600.00
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Biological Activity

JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).
In vitro DMSO 69 mg/mL (196.89 mM)
Water Insoluble
Ethanol 14 mg/mL (39.94 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.54 mL 142.68 mL 285.36 mL
0.5 mM 5.71 mL 28.54 mL 57.07 mL
1 mM 2.85 mL 14.27 mL 28.54 mL
5 mM 0.57 mL 2.85 mL 5.71 mL

*The above data is based on the productmolecular weight 350.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12925
Actions Inhibitor
CAS No. 315703-52-7
Formula C19H18N4OS
M. Wt 350.44
Purity >98%
Synonyms JK184
SMILES CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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