JNJ-28312141

Catalog No.: A12687

CSF1R inhibitor

JNJ-28312141

JNJ-28312141 Chemical Structure

CAS NO. 885692-52-4

JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $350.00

Special Price $315.00

10 mg

Regular Price: $650.00

Special Price $585.00

25 mg

Regular Price: $1,200.00

Special Price $1,080.00

50 mg

Regular Price: $2,000.00

Special Price $1,800.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.71 mL 108.56 mL 217.12 mL
0.5 mM 4.34 mL 21.71 mL 43.42 mL
1 mM 2.17 mL 10.86 mL 21.71 mL
5 mM 0.43 mL 2.17 mL 4.34 mL

*The above data is based on the productmolecular weight 460.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12687
Actions Inhibitor
M. Wt 460.57
Formula C26H32N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 885692-52-4
Synonyms JNJ 28312141, JNJ28312141
SMILES CN(C)CC(=O)N1CCC(CC1)C2=CC(=C(C=C2)NC(=O)C3=NC=C(N3)C#N)C4=CCCCC4

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