JNJ-7706621

Catalog No.: A10494

CDK/Aurora A/B Inhibitor

JNJ-7706621

JNJ-7706621 Chemical Structure

CAS NO. 443797-96-4

JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$210.00
50 mg
$500.00
100 mg
$860.00
10mM * 1mL in DMSO
$154.00
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Biological Activity

JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.
In vitro (25°C) DMSO 67 mg/mL (169.89 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% methylcellulose+0.2% Tween 80 13 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.35 mL 126.77 mL 253.55 mL
0.5 mM 5.07 mL 25.35 mL 50.71 mL
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL

*The above data is based on the productmolecular weight 394.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10494
Actions Inhibitor
CAS No. 443797-96-4
Formula C15H12F2N6O3S
M. Wt 394.4
Purity >98%
Synonyms JNJ7706621
SMILES C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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