Biological Activity
JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.
In vitro (25°C) | DMSO | 67 mg/mL (169.89 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 0.5% methylcellulose+0.2% Tween 80 | 13 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.35 mL | 126.77 mL | 253.55 mL |
0.5 mM | 5.07 mL | 25.35 mL | 50.71 mL |
1 mM | 2.54 mL | 12.68 mL | 25.35 mL |
5 mM | 0.51 mL | 2.54 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10494 |
---|---|
Actions | Inhibitor |
CAS No. | 443797-96-4 |
Formula | C15H12F2N6O3S |
M. Wt | 394.4 |
Purity | >98% |
Synonyms | JNJ7706621 |
SMILES | C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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