JNK/c-Jun

Catalog No.Inhibitor Name JNK1JNK2JNK3JNKOther
A10860SP600125
***
***
*
Aurora A,TrkA,FLT3
A12749JNK-IN-8
****
***
****
Kit (V559D,T670I),Kit (V559D),RIOK2
A11969JNK Inhibitor IX
*
**
A11296AS 602801 (Bentamapimod)
**
**
*
A13564CC-930 ( Tanzisertib)
**
***
****
A13565CEP-1347
***
A13683BI-78D3
*
A11352CC-401
A15061DB07268
****
A15136JNK-IN-7
IRAK1, PIK3C3, PIP5K3 and PIP4K2C
A16036IQ 3
*
*
**
NF-κB, AP1
A16039SU 3327
*
A16054TCS JNK 6o
****
****
**
A16062 IQ-1S
*
*
**
A15883Vacquinol-1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. DTP3

    Catalog No. A16059
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    JNK inhibitor
    DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-kB survival pathway. Learn More
  2. IQ 3

    Catalog No. A16036
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    JNK3 inhibitor
    IQ 3 is a selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-kB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro. Learn More
  3. SU 3327

    Catalog No. A16039
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    JNK inhibitor
    SU 3327 is a selective inhibitor of JNK (c-Jun N-terminal kinase)(IC50 = 0.7uM). SU 3327 is shown to inhibit the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Learn More
  4. JNK-IN-7

    Catalog No. A15136
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    JNK Inhibitor
    JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C. Learn More
  5. DB07268

    Catalog No. A15061
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    JNK1 inhibitor
    DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM. Learn More
  6. CC-401 hydrochloride

    Catalog No. A15037
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    JNK inhibitor
    CC-401 hydrochloride is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Learn More
  7. CEP-1347

    Catalog No. A13565
    JNK inhibitor
    CEP-1347 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. It rescues motor neurons undergoing apoptosis (EC50 = 20 nM). Learn More
  8. CC-930 (Tanzisertib)

    Catalog No. A13564
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    JNK inhibitor
    CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively Learn More
  9. BI-78D3

    Catalog No. A13683
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    JNK inhibitor
    BI-78D3 is a competitive JNK (c-Jun N-terminal kinases) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. BI 78D3 inhibits JIP1(JNK interacting protein 1)-JNK binding (IC50 = 500 nM). Learn More
  10. JNK-IN-8

    Catalog No. A12749
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    JNK Inhibitor
    JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively Learn More
  11. JIP-1 (153-163)

    Catalog No. A16041
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    JNK inhibitor
    JIP-1 (153-163) is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK. Learn More
  12. TCS JNK 6o

    Catalog No. A16054
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    JNK inhibitor
    TCS JNK 6o is a ATP-competitive and selective c-Jun N-terminal kinase (JNK) inhibitor. Learn More
  13. AEG 3482

    Catalog No. A11281
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    JNK inhibitor
    AEG 3482 is a small-molecule inhibitor of Jun kinase (JNK)-dependent apoptosis. Learn More
  14. c-JUN peptide

    Catalog No. A16045
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    JNK inhibitor
    c-JUN peptide is a peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Learn More
  15. SR 3576

    Catalog No. A16020
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    JNK3 inhibitor
    SR 3576 is a highly potent and selective JNK3 inhibitor (IC50 = 7 nM); exhibits > 2800-fold selectivity over p38. Learn More
  16. IQ-1S

    Catalog No. A16062
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    JNK3 inhibitor
    IQ-1S is a Selective JNK3 inhibitor with IC50 value of 390, 360 and 87 nM for JNK1, 2 and 3 respectively. Learn More
  17. TCS JNK 5a

    Catalog No. A11969
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    JNK Inhibitor IX
    TCS JNK 5a is a highly selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38?? respectively). Learn More
  18. CC-401

    Catalog No. A11352
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    JNK inhibitor
    CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Learn More
  19. AS 602801 (Bentamapimod)

    Catalog No. A11296
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    JNK inhibitor
    AS 602801 is a novel, orally active, Jun Kinase Inhibitor. Learn More
  20. SP600125

    Catalog No. A10860
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    JNK inhibitor
    SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3. Learn More

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