KU-60019

Catalog No.: A10507

ATM Inhibitor

KU-60019

KU-60019 Chemical Structure

CAS NO. 925701-49-1, 925701-46-8

KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.

Availability: In stock

Package Price Qty
10 mg
$90.00
50 mg
$300.00
100 mg
$500.00
10mM * 1mL in DMSO
$108.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Masaya Igase, .et al. Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma, Mol Ther Oncolytics, 2019, vol 15 PMID: 31650025
  • CHENGHUA LOU, .et al. Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells, Oncol Lett, 2016, Jul; 12(1): 295–300 PMID: 27347141

Biological Activity

KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.
Targets
ATM (Cell-free assay)
6.3 nM
In vitro DMSO 40 mg/mL (73.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol 30 mg/mL (54.77 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.26 mL 91.29 mL 182.58 mL
0.5 mM 3.65 mL 18.26 mL 36.52 mL
1 mM 1.83 mL 9.13 mL 18.26 mL
5 mM 0.37 mL 1.83 mL 3.65 mL

*The above data is based on the productmolecular weight 547.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10507
Actions Inhibitor
M. Wt 547.7
Formula C30H33N3O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 925701-49-1, 925701-46-8
Synonyms KU60019, KU-60019
SMILES C[[email protected]@H]1CN(C[[email protected]@H](O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6

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