KW-2478

Catalog No.: A11195

HSP90 inhibitor

KW-2478

KW-2478 Chemical Structure

CAS NO. 819812-04-9

KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$250.00
50 mg
$550.00
100 mg
$900.00
10mM * 1mL in DMSO
$231.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Biological Activity

KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.

Targets
HSP90
3.8 nM
In vitro (25°C) DMSO 114 mg/mL (198.37 mM)
Water Insoluble
Ethanol 3 mg/mL (5.22 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.4 mL 87.01 mL 174.02 mL
0.5 mM 3.48 mL 17.4 mL 34.8 mL
1 mM 1.74 mL 8.7 mL 17.4 mL
5 mM 0.35 mL 1.74 mL 3.48 mL

*The above data is based on the productmolecular weight 574.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11195
Actions Inhibitor
CAS No. 819812-04-9
Formula C30H42N2O9
M. Wt 574.66
Purity >98%
Synonyms KW2478
SMILES CCC1=C(C=C(C(=C1CC(=O)N(CCOC)CCOC)C(=O)C2=CC(=C(C=C2)OCCN3CCOCC3)OC)O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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