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Lapatinib Ditosylate

Catalog No.: A10514

HER2 inhibitor

Lapatinib Ditosylate

Lapatinib Ditosylate Chemical Structure

CAS NO. 388082-77-7

Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.

Availability: In stock

Package Price Qty
25 mg
50 mg
200 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.
Target Value
ErbB2IC50: 9.2nM
EGFRIC50: 10.8nM
ErbB4IC50: 367nM
c-SrcIC50: 3.5μM
C-Raf-1IC50: >10μM
MEKIC50: >10μM
ERKIC50: >10μM
c-FmsIC50: >10μM
CDK1IC50: >10μM
CDK2IC50: >10μM
p38IC50: >10μM
Tie-2IC50: >10μM
VEGFR2IC50: >10μM
In vitro (25°C) DMSO 93 mg/mL (100.49 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.81 mL 54.03 mL 108.05 mL
0.5 mM 2.16 mL 10.81 mL 21.61 mL
1 mM 1.08 mL 5.4 mL 10.81 mL
5 mM 0.22 mL 1.08 mL 2.16 mL

*The above data is based on the productmolecular weight 925.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10514
Actions Inhibitor
CAS No. 388082-77-7
Formula C43H42ClFN4O10S3
M. Wt 925.46
Purity >98%
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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