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Biological Activity
Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.
Targets
| Target | Value |
|---|---|
| ErbB2 | IC50: 9.2nM |
| EGFR | IC50: 10.8nM |
| ErbB4 | IC50: 367nM |
| c-Src | IC50: 3.5μM |
| C-Raf-1 | IC50: >10μM |
| MEK | IC50: >10μM |
| ERK | IC50: >10μM |
| c-Fms | IC50: >10μM |
| CDK1 | IC50: >10μM |
| CDK2 | IC50: >10μM |
| p38 | IC50: >10μM |
| Tie-2 | IC50: >10μM |
| VEGFR2 | IC50: >10μM |
| In vitro (25°C) | DMSO | 93 mg/mL (100.49 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 10.81 mL | 54.03 mL | 108.05 mL |
| 0.5 mM | 2.16 mL | 10.81 mL | 21.61 mL |
| 1 mM | 1.08 mL | 5.4 mL | 10.81 mL |
| 5 mM | 0.22 mL | 1.08 mL | 2.16 mL |
*The above data is based on the productmolecular weight 925.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10514 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 388082-77-7 |
| Formula | C43H42ClFN4O10S3 |
| M. Wt | 925.46 |
| Purity | >98% |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
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