LDN193189 HCl

Catalog No.: A11478

LDN193189 HCl Chemical Structure

CAS NO. 1062368-62-0

LDN193189 HCl is the hydrochloride salt of LDN193189. LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $70.00

Special Price $56.00

10 mg

Regular Price: $90.00

Special Price $72.00

25 mg

Regular Price: $160.00

Special Price $128.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

LDN193189 HCl is the hydrochloride salt of LDN193189. LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.
Targets
ALK2 (C2C12 cells) ALK3 (C2C12 cells)
5 nM30 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.58 mL 112.88 mL 225.76 mL
0.5 mM 4.52 mL 22.58 mL 45.15 mL
1 mM 2.26 mL 11.29 mL 22.58 mL
5 mM 0.45 mL 2.26 mL 4.52 mL

*The above data is based on the productmolecular weight 442.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11478
M. Wt 442.94
Formula C25H22N6.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1062368-62-0
Synonyms LDN 193189
SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl.Cl.Cl.Cl

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