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- Brandon J.Peiffer, .et al. Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing, Cell Chem Biol, 2019, 26, 1-10
Biological Activity
LDN193189 HCl is the hydrochloride salt of LDN193189. LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.
Targets
| ALK2 (C2C12 cells) | ALK3 (C2C12 cells) | |||
| 5 nM | 30 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.58 mL | 112.88 mL | 225.76 mL |
| 0.5 mM | 4.52 mL | 22.58 mL | 45.15 mL |
| 1 mM | 2.26 mL | 11.29 mL | 22.58 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
*The above data is based on the productmolecular weight 442.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11478 |
|---|---|
| CAS No. | 1062368-62-0 |
| Formula | C25H22N6.HCl |
| M. Wt | 442.94 |
| Purity | >98% |
| Synonyms | LDN 193189 |
| SMILES | C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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