Lipase

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  1. URB754

    Catalog No. A11095
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    Monoacylglycerol lipase inhibitor
    URB754 was originally reported to be a potent, noncompetitive inhibitor of monoacylglycerol lipase. Learn More
  2. MJN110

    Catalog No. A16081
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    MAGL inhibitor
    MJN110 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) with >10,000 selectivity over FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA). Learn More
  3. Cetilistat (ATL-962)

    Catalog No. A15944
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    lipase inhibitor
    Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Learn More
  4. JZL195

    Catalog No. A12390
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    dual FAAH/MAGL inhibitor
    JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively. Learn More
  5. JW-642

    Catalog No. A13774
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    MAGL inhibitor
    JW-642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. Learn More
  6. XEN445

    Catalog No. A13150
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    Endothelial lipase(EL) inhibitor
    XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Learn More
  7. Atglistatin

    Catalog No. A13814
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    ATGL inhibitor
    Atglistatin is a highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL) with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, but no toxicity up to a concentration of 50 μM. Learn More
  8. JZL184

    Catalog No. A12747
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    MAGL Inhibitor
    JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Learn More
  9. URB602

    Catalog No. A16359
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    MGL inhibitor
    URB602 is a selective inhibitor of monoglycerol lipase (MGL), exhibiting an IC50 of 28 μM for the rat brain enzyme. Learn More

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