Losmapimod (GW856553X)

Catalog No.: A12526

p38 MAPK inhibitor

Losmapimod (GW856553X) Chemical Structure

CAS NO. 585543-15-3

Losmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.

Availability: In stock

Package Price Qty
10 mg
$70.00
25 mg
$140.00
50 mg
$200.00
10mM * 1mL in DMSO
$86.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Losmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.
Targets
p38α p38β
8.1(pKi)7.6(pKi)
In vitro DMSO 76 mg/mL (198.19 mM)
Water <1 mg/mL (<1 mM)
Ethanol 41 mg/mL heating (106.92 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.08 mL 130.39 mL 260.78 mL
0.5 mM 5.22 mL 26.08 mL 52.16 mL
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL

*The above data is based on the productmolecular weight 383.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12526
Actions Inhibitor
M. Wt 383.46
Formula C22H26FN3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 585543-15-3
Synonyms GW856553, GW-856553, GW 856553, GW856553X
SMILES CC1=C(C=C(C=C1C2=NC=C(C=C2)C(=O)NCC(C)(C)C)C(=O)NC3CC3)F

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