Losmapimod (GW856553X)

Catalog No.: A12526

p38 MAPK inhibitor

Losmapimod (GW856553X)

Losmapimod (GW856553X) Chemical Structure

CAS NO. 585543-15-3

Losmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.

Availability: In stock

Package Price Qty
10 mg
$70.00
25 mg
$140.00
50 mg
$200.00
10mM * 1mL in DMSO
$86.00
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Biological Activity

Losmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.
Targets
p38α p38β
8.1(pKi)7.6(pKi)
In vitro DMSO 72 mg/mL (187.76 mM)
Water Insoluble
Ethanol Warmed: 39 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.08 mL 130.39 mL 260.78 mL
0.5 mM 5.22 mL 26.08 mL 52.16 mL
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL

*The above data is based on the productmolecular weight 383.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12526
Actions Inhibitor
CAS No. 585543-15-3
Formula C22H26FN3O2
M. Wt 383.46
Solubility DMSO
Purity >98%
Synonyms GW856553, GW-856553, GW 856553, GW856553X
SMILES CC1=C(C=C(C=C1C2=NC=C(C=C2)C(=O)NCC(C)(C)C)C(=O)NC3CC3)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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