Catalog No.: A10543

BACE1 inhibitor


LY2886721 Chemical Structure

CAS NO. 1262036-50-9

LY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments.

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Naomi Ito, .et al. miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation, Br J Pharmacol, 2017, Mar; 174(5): 386-395 PMID: 28012171

Biological Activity

LY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments.
In vitro DMSO 9 mg/mL (23.05 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.61 mL 128.07 mL 256.15 mL
0.5 mM 5.12 mL 25.61 mL 51.23 mL
1 mM 2.56 mL 12.81 mL 25.61 mL
5 mM 0.51 mL 2.56 mL 5.12 mL

*The above data is based on the productmolecular weight 390.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10543
Actions Inhibitor
CAS No. 1262036-50-9
Formula C18H16F2N4O2S
M. Wt 390.4
Purity >98%
Synonyms LY-2886721
SMILES C1[[email protected]]2CSC(=N[[email protected]]2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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