c-MET

Catalog No.Inhibitor Name c-MetOther
A10712Crizotinib
*
ALK
A10996Cabozantinib
***
VEGFR2/KDR,Kit,VEGFR3/FLT4
A10998Foretinib
****
KDR,Tie-2,VEGFR3/FLT4
A10713PHA-665752
**
RON,Flk1,c-Abl
A10869SU11274
**
Flk1,RON,FGFR1
A10839SGX-523
***
A10153BMS-777607
***
Axl,RON,Tyro3
A11087Tivantinib
*
A10493JNJ-38877605
***
A10711PF-04217903
**
A10587MGCD-265
****
RON,VEGFR2,VEGFR1
A11132Capmatinib
****
A11059BMS-754807
**
Insulin Receptor,IGF-1R,TrkB
A10154BMS-794833
***
VEGFR2
A10063AMG-208
**
A11753MK-2461
****
c-Met (Y1235D),c-Met (Y1230C),c-Met (N1100)
A11396Golvatinib
*
VEGFR2
A11055AMG-458
****
VEGFR2
A11257Tepotinib
***
IRAK4,TrkA,Axl
A11150NVP-BVU972
*
A12557Merestinib
***
A15917NPS-1034
*
Axl
A11489MK-8033
****
Ron
A14387Altiratinib
***
TIE-2, VEGFR
A14419Volitinib (Savolitinib, AZD-6094)
A15792BMS-817378
***
VEGFR2

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

32 Item(s)

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  1. PF-2341066 (Crizotinib)

    Catalog No. A10712
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    ALK/ c-Met inhibitor
    PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Learn More
  2. LY2801653 dihydrochloride

    Catalog No. A15150
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    MET inhibitor
    LY2801653 dihydrochloride is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM). Learn More
  3. PF-04217903 methanesulfonate

    Catalog No. A15208
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    c-Met Inhibitor
    PF-04217903 methanesulfonate is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant). Learn More
  4. BMS-817378

    Catalog No. A15792
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    MET/VEGFR-2 inhibitor
    BMS-817378 is a novel prodrug of the dual Met/VEGFR-2 inhibitor BMS-794833. Learn More
  5. Altiratinib (DCC2701)

    Catalog No. A14387
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    c-Met/VEGFR inhibitor
    Altiratinib is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Learn More
  6. NPS-1034

    Catalog No. A15917
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    c-Met inhibitor
    NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively. Learn More
  7. LY2801653 (Merestinib)

    Catalog No. A12557
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    c-MET inhibitor
    LY2801653 is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM). Learn More
  8. c-Met inhibitor 2

    Catalog No. A16256
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    c-Met inhibitor
    c-Met inhibitor 2 is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor. Learn More
  9. Glesatinib hydrochloride

    Catalog No. A16257
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    MET/Axl inhibitor
    Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered. Learn More
  10. MK-8033

    Catalog No. A11489
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    c-Met inhibitor
    MK-8033 is a novel and specific dual ATP competitive c-Met/Ron inhibitor (IC50=1 nM Wt c-Met) under investigation as a treatment for cancer. Learn More
  11. EMD-1214063

    Catalog No. A11257
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    c-Met Inhibitor
    EMD-1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. It binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase. Learn More
  12. MK-2461

    Catalog No. A11753
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    c-Met Inhibitor
    MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Learn More
  13. E-7050 (Golvatinib)

    Catalog No. A11396
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    E7050 (also known as golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. Learn More
  14. Volitinib (Savolitinib, AZD-6094)

    Catalog No. A14419
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    c-Met inhibitor
    Volitinib is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity. Learn More
  15. c-Met inhibitor 1

    Catalog No. A15049
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    c-Met inhibitor
    c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer. Learn More
  16. INCB28060

    Catalog No. A11132
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    c-MET Inhibitor
    INCB28060, a novel inhibitor of c-MET kinase. INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. Learn More
  17. NVP-BVU972

    Catalog No. A11150
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    C-Met inhibitor
    NVP-BVU972 is a selective MET inhibitor. Learn More
  18. XL184 free base (Cabozantinib)

    Catalog No. A10996
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    VEGFR inhibitor
    XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More
  19. Foretinib (GSK1363089, XL880)

    Catalog No. A10998
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    c-MET inhibitor
    Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis. Learn More
  20. SU11274

    Catalog No. A10869
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    c-Met inhibitor
    SU11274 is a Met tyrosine kinase inhibitor. Learn More
  21. PHA-665752

    Catalog No. A10713
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    c-Met Inhibitor
    PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling. Learn More
  22. SGX-523

    Catalog No. A10839
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    c-Met Inhibitor
    SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway. Learn More
  23. JNJ-38877605

    Catalog No. A10493
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    c-Met inhibitor
    c-Met inhibitor JNJ-38877605 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. Learn More
  24. BMS-777607

    Catalog No. A10153
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    c-Met inhibitor
    BMS-777607 is a MET tyrosine kinase inhibitor that binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway. Learn More
  25. MGCD-265 (Glesatinib)

    Catalog No. A10587
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    c-Met inhibitor
    MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs, including the c-Met receptor (HGFR); the Tek/Tie-2 receptor; VEGFR types 1, 2, and 3; and MST1R. Learn More
  26. PF-04217903

    Catalog No. A10711
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    c-Met Inhibitor
    PF-04217903 is a novel c-Met/hepatocyte growth factor receptor tyrosine kinase inhibitors. Learn More
  27. AMG 208

    Catalog No. A10063
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    c-Met Inhibitor
    AMG 208 is a novel c-Met inhibitor that inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity. Learn More
  28. BMS-794833

    Catalog No. A10154
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    c-Met inhibitor
    BMS-794833 is a potent ATP competitive inhibitor to Met and VEGFR-2 with IC50 of 1.7 and 15 nmol. Learn More
  29. AMG-458

    Catalog No. A11055
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    c-Met inhibitor
    AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2. Learn More
  30. BMS-754807

    Catalog No. A11059
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    IGF-1R inhibitor
    BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents. Learn More
  31. ARQ 197

    Catalog No. A11087
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    c-Met inhibitor
    ARQ-197 is a selective inhibitor of the c-Met receptor tyrosine kinase Learn More
  32. AMG 337

    Catalog No. A16400
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    MET inhibitor
    AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the MET receptor. Learn More

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