Microtubule/Tubulin

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  1. Microtubule Associated inhibitor

    Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division.
  2. microtubule assembly inhibitor

    4-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.
  3. Microtubule Associated inhibitor

    ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis.
  4. Microtubule Inhibitor

    CYT997 is a novel anti-cancer vascular disrupting agent (VDA). In vitro, CYT997 is shown to potently inhibit the proliferation of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells (IC(50) 3.7 ?? 1.8 nM) and cause significant morphological changes at 100 nM, including membrane blebbing.
  5. Microtubule Associated inhibitor

    Docetaxel (Taxotere) is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions.
  6. Microtubule Associated inhibitor

    Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.
  7. Microtubule Associated inhibitor

    Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.
  8. Tubulin inhibitor

    Vincristine is a mitotic inhibitor, and is used in cancer chemotherapy.
  9. Microtubule Associated inhibitor

    Vinflunine Tartrate is a tartrate salt of vinflunine that destabilizes microtubules with an IC50 of 18.8 nM and interferes with the dynamics of microtubules during cell division.
  10. microtubule inhibitor

    Ixabepilone is an epothilone B analog
  11. Microtubule Associated inhibitor

    Cabazitaxel is a semi-synthetic derivative of a natural taxoid. Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment
  12. microtubule inhibitor

    Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.
  13. microtubule dynamics inhibitor

    Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
  14. Microtubule Associated inhibitor

    CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP.
  15. Arp2/3 inhibitor

    CK-636 is a Arp2/3 complex inhibitor. CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation.
  16. Hec1 imhibitor

    INH1 is a Hec1 inhibitor. It binds Hec1, inhibiting its association with Nek2 and kinetochores.
  17. Hec1 Inhibitor

    INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
  18. Tubulin inhibitor

    D-64131 is a novel inhibitor of tubulin polymerization that inhibits tumor cell proliferation in vitro (IC50 = 74 nM).
  19. Microtubule polymerization inhibitor

    Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. Also it is an potent Microtubule polymerization inhibitor
  20. Tubulin inhibitor

    Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate; Mc-MMAD is a protective group (maleimidocaproyl) -conjugated MMAD.
  21. Tubulin inhibitor

    MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
  22. Tubulin inhibitor

    Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate.
  23. maytansinoid microtubular inhibitor

    DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group.
  24. tau protein aggregation inhibitor

    TRx 0237 (LMT) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
  25. tubulin polymerization inhibitor

    Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity.
  26. Microtubule/Tubulin Inhibitor

    SSE15206 is a pyrazolinethioamide derivative that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.
  27. Microtubule inhibitor

    VCP-Eribulin consists the ADCs linker (VCP) and Eribulin. Eribulin is a mechanistically unique microtubule inhibitor for cancer. VCP-Eribulin is an Eribulin-based drug for antibody conjugates.
  28. Microtubule inhibitor

    Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin. Eribulin is a mechanistically unique microtubule inhibitor for cancer. Mal-PEG2-VCP-Eribulin is an Eribulin-based drug for antibody conjugates.
  29. oral α and β tubulin inhibitor

    VERU-111 is a novel, oral α and β tubulin inhibitor that blocks tubulin polymerization and is not a substrate for multi-drug resistance mechanisms.
  30. CPAP-tubulin interaction inhibitor

    CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity.
  31. INH inhibitor

    INH154 is a highly potent inhibitor for Nek2 and Hec1 binding (INH), with IC50s of 200 nM and 120 nM for INH in Hela and MB468 cells.
  32. Microtubule assembly inhibitor

    Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79?nM, and exhibits a broad-spectrum anthelmintic activity.
  33. Kif18A inhibitor

    BTB-1 is a potent, selective and reversible mitotic motor protein Kif18A inhibitor with an IC50 of 1.69 μM.
  34. tubulin inhibitor

    Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization.
  35. microtubulin inhibitor

    Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.
  36. tubulin polymerization inhibitor

    BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
  37. Arp2/3 complex inhibitor

    CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.
  38. Arp2/3 complex inhibitor

    CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.
  39. β-tubulin polymerization inhibitor

    Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity.
  40. Tubulin assembly inhibitor

    Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity.
  41. tubulin polymerization inhibitor

    Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization.
  42. β-tubulin polymerization inhibitor

    Valecobulin (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.
  43. microtubule inhibitor

    Rosabulin is a potent microtubule inhibitor, with anti-cancer activities.
  44. tubulin polymerization inhibitor

    McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.
  45. Tau and Aβ aggregation inhibitor

    PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively.
  46. mitotic/tubulin inhibitor

    D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
  47. tubulin polymerisation inhibitor

    Lexibulin 2Hcl (CYT-997 2Hcl) is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo.
  48. auristatin microtubule inhibitor

    PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue.
  49. microtubule assembly and microtubule dynamics inhibitor

    Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics.

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