MK-0812

Catalog No.: A11127

CCR2 antagonist

MK-0812

MK-0812 Chemical Structure

CAS NO. 624733-88-6

MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes and low nM in the chemotaxis assay. It has good PK profiles in preclinical species and demonstrated efficacy in animal models.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $195.00

Special Price $156.00

10 mg

Regular Price: $360.00

Special Price $288.00

50 mg

Regular Price: $1,500.00

Special Price $1,200.00

100 mg

Regular Price: $2,500.00

Special Price $2,000.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes and low nM in the chemotaxis assay. It has good PK profiles in preclinical species and demonstrated efficacy in animal models.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.5 mL 212.99 mL
0.5 mM 4.26 mL 21.3 mL 42.6 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11127
Actions Antagonist
M. Wt 469.5
Formula C24H34F3N3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 624733-88-6
Synonyms MK0812
SMILES CC(C)[[email protected]@]1(CC[[email protected]](C1)N[[email protected]]2CCOC[[email protected]]2OC)C(=O)N3CCC4=NC=C(C=C4C3)C(F)(F)F

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