MK-2461

Catalog No.: A11753

c-Met Inhibitor

MK-2461

MK-2461 Chemical Structure

CAS NO. 917879-39-1

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

Availability: In stock

Package Price Qty
5 mg
$180.00
10 mg
$320.00
25 mg
$650.00
50 mg
$1,150.00
10mM * 1mL in DMSO
$237.00
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Biological Activity

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.
Targets
Target Value
c-Met(M1250T)IC50: 0.4nM
c-Met(Y1235D)IC50: 0.5nM
c-Met(Y1230H)IC50: 1.0nM
c-Met(N1100)IC50: 1.5nM
c-Met(Y1230C)IC50: 1.5nM
c-MetIC50: 2.5nM
RONIC50: 7nM
FLT1IC50: 10nM
FLT3IC50: 22nM
PDGFRβIC50: 22nM
MerIC50: 24nM
FGFR2IC50: 39nM
KDRIC50: 44nM
TrkAIC50: 46nM
FGFR3IC50: 50nM
TrkBIC50: 61nM
FGFR1IC50: 65nM
FLT4IC50: 78nM
DRAK1IC50: 199nM
JAK2IC50: 225nM
IRAK4IC50: 298nM
MELKIC50: 606nM
RETIC50: 635nM
DYRK2IC50: 1.143μM
MLK1IC50: 4.303μM
IRAK1IC50: 5.459μM
AblIC50: 7.747μM
In vitro (25°C) DMSO 95 mg/mL (191.7 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80, pH 4 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.18 mL 100.89 mL 201.78 mL
0.5 mM 4.04 mL 20.18 mL 40.36 mL
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

*The above data is based on the productmolecular weight 495.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11753
Actions Inhibitor
CAS No. 917879-39-1
Formula C24H25N5O5S
M. Wt 495.6
Solubility DMSO
Purity >98%
Synonyms MK2461
SMILES CN1C=C(C=N1)C2=CN=C3C=CC4=C(C=C(C=C4)NS(=O)(=O)N(C)C[[email protected]@H]5COCCO5)C(=O)C3=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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