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MK-4305 (Suvorexant)


OX receptor antagonist

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Catalog No. A11500

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
MK-4305 (Suvorexant) 5mg A11500-5

Regular Price: $90.00

Special Price: $81.00

MK-4305 (Suvorexant) 10mg A11500-10

Regular Price: $160.00

Special Price: $144.00

MK-4305 (Suvorexant) 25mg A11500-25

Regular Price: $350.00

Special Price: $315.00

MK-4305 (Suvorexant) 50mg A11500-50

Regular Price: $600.00

Special Price: $540.00

MK-4305 (Suvorexant) 10mM * 1mL in DMSO A11500-10mM-D

Regular Price: $140.00

Special Price: $126.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.

MK-4305 (Suvorexant)

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Publications citing Adooq Products
MK-4305 (Suvorexant) Citations (6)
  • Obara K, .et al. Assessment of Inhibitory Effects of Hypnotics on Acetylcholine-Induced Contractions in Isolated Rat Urinary Bladder Smooth Muscle, Biol Pharm Bull, 2019, 42(2):280-288 PMID: 30713259
  • James B Jaggard, .et al. Hypocretin underlies the evolution of sleep loss in the Mexican cavefish, eLife, 2018, 7: e32637 PMID: 29405117
  • Skillman B, .et al. Quantification of suvorexant in blood using liquid chromatography-quadrupole/time of flight (LC-Q/TOF) mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci, 2018, Aug 1;1091:87-95 PMID: 29859493
  • Clark L, .et al. On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies, J Biomol NMR, 2018, Aug;71(4):203-211 PMID: 30121871
  • Sullinger S, .et al. Identification of Suvorexant in Urine Using Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry (LC-Q/TOF-MS), J Anal Toxicol, 2017, Apr 1;41(3):224-229 PMID: 28035034
  • Carson M, .et al. Quantification of suvorexant in urine using gas chromatography/mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci, 2017, Jan 1;1040:289-294 PMID: 27825624

Chemical Information

Catalog Num A11500
Actions Antagonist
M. Wt 450.92
Formula C23H23ClN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1030377-33-3
Synonyms MK4305, MK 4305
SMILES C[[email protected]@H]1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl

Biological Activity

Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.
OX2 receptor OX1 receptor
0.35 nM(Ki)0.55 nM(Ki)


Solubility (25°C)* In vitro DMSO 10 mg/mL (22.17 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.18 mL 110.88 mL 221.77mL
0.5 mM 4.44 mL 22.18 mL 44.35 mL
1 mM 2.22 mL 11.09 mL 22.18 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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