MK-5108 (VX-689)

Catalog No.: A11410

Aurora A Kinase inhibitor

MK-5108 (VX-689) Chemical Structure

CAS NO. 1010085-13-8

MK-5108, also known as VX-689, is a competitive inhibitor of the ATP-binding site of aurora A kinase.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$170.00
50 mg
$450.00
100 mg
$750.00
10mM * 1mL in DMSO
$120.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

MK-5108, also known as VX-689, is a competitive inhibitor of the ATP-binding site of aurora A kinase.
Targets
Aurora A (Cell-free assay)
0.064 nM
In vitro (25°C) DMSO 92 mg/mL (199.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.65 mL 108.25 mL 216.5 mL
0.5 mM 4.33 mL 21.65 mL 43.3 mL
1 mM 2.16 mL 10.82 mL 21.65 mL
5 mM 0.43 mL 2.16 mL 4.33 mL

*The above data is based on the productmolecular weight 461.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11410
Actions Inhibitor
M. Wt 461.9
Formula C22H21ClFN3O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1010085-13-8
Synonyms MK5108, VX689
SMILES C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O

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