nAChR

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  1. EVP-6124 (Encenicline)

    Catalog No. A15086
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    nAChR Inhibitor
    EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs); shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs. Learn More
  2. Mecamylamine Hydrochloride

    Catalog No. A17884
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    nAChR antagonist
    Mecamylamine hydrochloride is a nAChR antagonist previously used to treat hypertension. It displays a wide variety of activities, including reducing depression-like behaviors in subjects with Tourette's syndrome and improving rates of smoking cessation. Learn More
  3. Benzethonium Chloride

    Catalog No. A13653
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    nAChR inhibitor
    Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively. Learn More
  4. GTS-21 (DMBX-A)

    Catalog No. A15950
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    nAChR agonist
    GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Learn More
  5. EVP-6124 hydrochloride

    Catalog No. A15087
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    nAChR Inhibitor
    EVP-6124 hydrochloride is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). EVP-6124 showed selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs. Learn More
  6. A-582941

    Catalog No. A13539
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    α7 nAChR agonist
    A-582941 is a selective AChR a7 partial agonist. It exhibits high affinity for both rat and human a7 receptors (Ki values are 10.8 and 16.7 nM, respectively). Learn More
  7. 5-Iodo-A-85380 2HCl

    Catalog No. A13639
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    nAChR agonist
    5-Iodo-A-85380 2HCl is a highly potent and subtype-selective agonist for the a4b2 and a6b2 nicotinic acetylcholine receptors. Learn More
  8. ABT-418 HCl

    Catalog No. A13688
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    nAChR agonist
    ABT-418 HCl is a neuronal nicotinic acetylcholine receptor agonist. Learn More
  9. Sofinicline (ABT-894, A-422894)

    Catalog No. A13842
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    nAChR agonist
    Sofinicline is a novel nicotinic acetylcholine receptor agonist in the treatment of attention-deficit/hyperactivity disorder. Learn More
  10. Ispronicline (TC-1734, AZD-3480)

    Catalog No. A14183
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    nAChR agonist
    Ispronicline is a neuronal nicotinic acetylcholine receptor partial agonist. Ispronicline is subtype-selective, binding primarily to the a4b2 subtype. It has antidepressant, nootropic and neuroprotective effects. Learn More
  11. A-867744

    Catalog No. A11290
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    modulator of α7 nAChRs
    A-867744 is a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. Learn More
  12. PNU 282987

    Catalog No. A11233
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    α7 nAChR agonist
    PNU 282987 (PNU-282,987)is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors. Learn More
  13. (-)-(S)-B-973B

    Catalog No. A18761
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    α7 nAChR modulator
    -)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity. Learn More
  14. Bephenium hydroxynaphthoate

    Catalog No. A17391
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    B-type AChR activator
    Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis; B-type AChR activator. Learn More
  15. CCMI

    Catalog No. A21534
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    α7 nAChR-positive allosteric modulator
    CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. Learn More
  16. BNC375

    Catalog No. A18503
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    α7 nAChR Modulator
    BNC375 is a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs. Learn More
  17. Varenicline Hydrochloride

    Catalog No. A21539
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    α4β2 nAChR partial agonist
    Varenicline Hydrochloride (CP 526555 hydrochloride) is a high affinity, selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist and full α7 nAChR agonist. Learn More
  18. Tebanicline hydrochloride

    Catalog No. A21918
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    nAChR modulator
    Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. Learn More
  19. PNU-120596

    Catalog No. A11203
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    Nicotinic (α7) Receptor Modulator
    PNU-120596 is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors. Learn More
  20. Tropisetron HCL

    Catalog No. A14375
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    5-HT3 receptor antagonist
    Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. Learn More
  21. Methyllycaconitine citrate

    Catalog No. A12681
    Methyllycaconitine citrate is a potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Learn More
  22. Adiphenine HCl

    Catalog No. A11716
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    AChR inhibitor
    Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug Learn More
  23. Varenicline

    Catalog No. A10966
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    nAChR partial agonist
    Varenicline is a nicotinic receptor partial agonist. Learn More
  24. Bephenium

    Catalog No. A21680
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    AChR activator
    Bephenium is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis; B-type AChR activator. Learn More

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