Neuronal Signaling

Items 151-200 of 576

per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Product Citation
  1. BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42.
  2. COX-1 inhibitor

    SC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain.
  3. COX-1 and COX-2 inhibitor

    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
  4. Arecoline is a cholinergic alkaloid from seeds of the betel nut palm Areca catechu.
  5. AChE inhibitor

    Donepezil is a noncompetitive acetylcholineesterase inhibitor, which can readily cross the blood brain barrier and increase the concentration of cortical acetylcholine. It is known that Donepezil is a useful tool in the study of Alzheimer's disease.
  6. alpha-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblas.
  7. COMT inhibitor

    opicapone is a novel catechol-O-methyltransferase inhibitor
  8. COX-2 inhibitor?€?

    NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
  9. P2X3/P2X2/3 receptor antagonist

    AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
  10. NMDA receptors Blocker

    Ro 25-6981 is a high-affinity, potent and selective blocker of N-methyl- D-aspartate (NMDA) receptors.
  11. GABA reuptake inhibitor

    Tiagabine is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
  12. Gamma-secretase modulator

    TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo.
  13. COX-2 inhibitor

    Bromfenac sodium is a topically selective cyclooxygenase (COX)-2 inhibitor
  14. nonsteroidal glucocorticoid receptor agonist

    AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist.
  15. CaM kinase II inhibitor

    KN-93 is an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase.
  16. Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
  17. COX-2 Inhibitor

    FK3311 is a cell-permeable and orally available sulfonanilide that acts as a selective COX-2 inhibitor and NSAID.
  18. COX inhibitor

    Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.
  19. COX-1 inhibitor

    Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively.
  20. COX-2 inhibitor

    Valdecoxib, also known as SC-65872, is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor.
  21. Benzodiazepine receptor/GABAA receptor agonist

    U-101017 is a partial agonist of benzodiazepine receptor and GABAA receptor, with anxiolytic effects.
  22. NMDA receptor antagonist

    RPR104632 is a specific antagonist of NMDA receptor, with potent neuroprotective properties.
  23. BzR agonist

    Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds to GABA(-) and GABA(+) ligand with Kis of 5.15 and 6.11 nM, respectively.
  24. NMDA receptor antagonist.

    (-)-MK 801 maleate acts as a potent, selective, and non-competitive NMDA receptor antagonist. It acts by binding to a site located within the NMDA associated ion channel.
  25. NMDA receptor antagonist

    GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist.
  26. eEF2K (CAMKIII) inhibitor

    A-484954 is a potent, selective inhibitor of eukaryotic longation factor-2 kinase (eEF2K).
  27. GABAA receptor modulator

    Lorediplon is a novel non-benzodiazepine, hypnotic drug acting as a GABAA receptor modulator,
  28. GABA(A) receptor agonist

    Muscimol hydrobromide is a potent but toxic structural analog of g-aminobutyric acid (GABA), with a zwitterionic structure.
  29. α7 nAChR agonist

    A-582941 is a selective AChR a7 partial agonist. It exhibits high affinity for both rat and human a7 receptors (Ki values are 10.8 and 16.7 nM, respectively).
  30. muscarinic M(3) receptor antagonist

    PF-3635659 is a potent muscarinic M(3) receptor antagonist.
  31. COX-2 inhibitor

    Parecoxib is a potent and selective COX-2 inhibitor.
  32. NMDAR modulator

    GLYX-13 is a selective weak partial agonist of the glycine site of the NMDA receptor which is under development by Naurex as adjunctive therapy for treatment-resistant depression.
  33. GABA uptake inhibitor

    Guvacine hydrochloride inhibits GABA uptake (IC50 values are 14, 58, 119 and 1870 uM for hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1 respectively).
  34. nAChR agonist

    5-Iodo-A-85380 2HCl is a highly potent and subtype-selective agonist for the a4b2 and a6b2 nicotinic acetylcholine receptors.
  35. nAChR inhibitor

    Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
  36. gamma-secretase inhibitor

    Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID).
  37. SPPL2a inhibitor

    SPL-707 is a potent, selective and orally available signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 80 nM.
  38. mAChR agonist

    Xanomeline oxalate is a potent agonist of muscarinic acetylcholine receptors (EC50 values are 0.3, 92.5, 5, 52, and 42 nM for M1, M2, M3, M4, and M5, respectively).
  39. benzodiazepine1 (BZ1) receptor agonist

    SX-3228 is a selective benzodiazepine1 (BZ1) receptor agonist with an IC50 of 17 nM.
  40. nAChR agonist

    ABT-418 HCl is a neuronal nicotinic acetylcholine receptor agonist.
  41. GABAB receptors antagonist

    2-Hydroxysaclofen is a potent and selective antagonist at GABAB receptors.
  42. GABAA receptor agonist

    AWD 131-138 is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.
  43. NMDA receptor antagonist

    MDL-29951 is a novel glycine antagonist of NMDA receptor activation (Ki=0.14 mM, [3H]glycine binding) in vitro and in vivo.
  44. (-)-Nicotine ditartrate is a potent agonist of AChR (nicotinic acetylcholine recepto).
  45. GABAA receptor modulator

    Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner.
  46. COX-2 inhibitor

    Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.
  47. GABAA agonist

    Bretazenil, a benzodiazepine receptor partial agonist, as an adjunct in the prophylactic treatment of OP poisoning.
  48. Ethyl dirazepate is a drug which is a benzodiazepine derivative. It has anxiolytic and hypnotic and possibly other characteristic benzodiazepine properties.
  49. PKD inhibitor

    CID755673 is a potent PKD inhibitor with IC50s of 182 nM, 280 nM and 227 nM for PKD1, PKD2 and PKD3, respectively.
  50. PKD1 inhibitor

    CID797718 is a structural analog of CID755673 (Adooq Catalog No. A13804). It was a 10-time less potent PKD1 inhibitor with an IC50 value of 7.0 +/-0.8 uM.

Items 151-200 of 576

per page
Set Descending Direction