New Products

Catalog No. Product Name Application Information
A17235
SBI-115
GPCR19 antagonist
SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.
A17219
MLS0315771
MPI inhibitor
MLS0315771 is a potent competitive phosphomannose isomerase (MPI) inhibitor.
A17238
Ro 08-2750
NGF inhibitor
Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM).
A17224
Sulfabromomethazine
Sulfabromomethazine, also known as Bromosulfamethazine, NSC 5874, SN 3517, is a long-acting derivative of sulfamezathine that is used in the poultry, swine and cattle industries for the treatment of coccidiosis.
A17242
PSMA617 TFA
PSMA-617, also know as vipivotide tetraxetan. It is a ligand used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer.
A17227
AG1295
PDGFR inhibitor
AG1295 is a PDGF receptor specific inhibitor.
A17237
SAR-7334 HCl
TRPC6 inhibitor
SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected.
A17231
NUN82647
NUN82647, also known as QBS or 2-Amino-N-quinolin-8-yl-benzenesulfonamide, is an Inhibitor of cell cycle at G2 phase; apoptosis inducer.
A17230
BIBF0775
TGFβRI inhibitor
BIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI).
A17228
MDL-800
SIRT6 allosteric activator
MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator.
A17244
Fevipiprant
CRTh2 receptor antagonist
Fevipiprant, also known as NVP-QAW039 or QAW039, is an oral active and potent CRTh2 receptor antagonist and potentially useful for asthma treatment.
A17221
PF-06371900
LRRK2 inhibitor
PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor.
A17223
MRTX1257
KRAS-G12C inhibitor
MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.
A17233
BUN60856
cFMS Receptor Inhibitor
BUN60856, also known as cFMS Receptor Inhibitor II, is a cFMS inhibitor.
A17217
Pelitrexol (AG-2037)
GARFT inhibitor
Pelitrexol is a GARFT inhibitor, and is also a water soluble antifolate with anti-proliferative activity.
A17240
Incyclinide
MMP inhibitor
Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
A17236
DC661
PPT1 inhibitor
DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor. DC661 inhibits autophagy. DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ).
A17216
BAY-876
GLUT1 Inhibitor
BAY-876 is a potent and Selective GLUT1 Inhibitor. BAY-876 showed good metabolic stability in vitro and high oral bioavailability in vivo.
A17220
NPI64
Protease inhibitor
NPI64 is a broad-spectrum coronavirus protease inhibitor which inhibits viral 3C and 3C-like protease.
A17226
Mivebresib (ABBV-075)
BET inhibitor
Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity.
A17241
Autophinib
Autophagy inhibitor
Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34.
A17229
KC01
ABHD16A inhibitor
KC01 is a covalent inhibitor of ABHD16A.
A17218
MX1013
pan-caspase inhibitor
MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1, caspase-3, and caspase-6, 7, 8, and 9.
A17225
AZ304
dual BRAF inhibitor
AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.
A17243
SNJ-1945
Calpain inhibitor
SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly.
A17222
Ras-IN-3144
pan-RAS inhibitor
Ras-IN-3144 is a pan-RAS inhibitor which inhibits RAS signaling pathways in cancer cells and prevents the growth of RAS mutant mouse cancer xenografts.
A17232
PUN30119
PUN30119, also known as Imidazole ketone erastin (IKE), is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.
A17239
CCT245737
CHK1 inhibitor
CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.
A17245
Firocoxib
COX-2 inhibitor
Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses.
A17234
KL1333
NAD+ Modulator
KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL-1333 Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts.
A17142
AG-494
EGFR inhibitor
AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells.
A17159
TRC051384
Hsp70 inducer
TRC051384 is an inducer of heat shock protein Hsp70.
A17130
XMD16-5
TNK2 inhibitor
XMD16-5 is a tyrosine kinase nonreceptor 2(TNK2) inhibitor.
A17162
ISCK03
c-kit inhibitor
ISCK03 is a potent c-kit inhibitor.
A17153
SU 5205
VEGFR2 inhibitor
SU 5205 is a VEGFR2 inhibitor.
A17136
TCS-OX2-29 HCl
OX2 receptor antagonist
TCS-OX2-29 is a selective OX2 receptor antagonist with IC50 value of 40 nM. CAS: 1610882-30-8 (HCl) 372523-75-6 (Free Base)
A17146
AG-126
ERK2 inhibitor
AG-126 is a ERK2 inhibitor that selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM.
A17014
MZ1
BRD4 protein degrader
MZ1 is a potent inducer of reversible, long-lasting and selective removal of BRD4 over BRD2 and BRD3.
A17122
COH000
SUMO E1 Inhibitor
COH000 is a highly specific covalent allosteric SUMO E1 inhibitor with an IC50 of 0.2 μM for SUMOylation in vitro.
A17117
SKA-31
potassium channel activator
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels.
A17155
KIN-1148
IRF3 agonist
KIN-1148, a small-molecule IRF3 agonist, functions as an influenza vaccine adjuvant by modulating the antiviral immune response.
A17125
CZC-25146
LRRK2 inhibitor
CZC-25146 is a potent LRRK2 inhibitor.
A17118
TR-14035
Integrin Antagonist
TR-14035 is a dual antagonist of α4β7 and α4β1 integrins.
A17134
XMD8-87
TNK2 Inhibitor
XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 μM
A17154
SU-5408
VEGFR2 Kinase Inhibitor
SU-5408, also known as VEGFR2 Kinase Inhibitor I, is a potent, cell-permeable inhibitor of mouse VEGFR2 kinase with IC50 value of 70 nM.
A17127
YHO-13177
BCRP/ABCG2 inhibitor
YHO-13177 is a potent and specific inhibitor of breast cancer resistance protein (BCRP/ABCG2).
A17157
SMI-16a
Pim kinase inhibitor
SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.
A17129
BIO
GSK3 inhibitor
BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β with IC50 value of 5 nM.
A17126
FX1
BCL6 inhibitor
FX1 is an inhibitor of the transcription factor B cell lymphoma 6 (BCL6) with IC50 value of ~35 μM.
A17065
BCI-121
SMYD3 inhibitor
BCI-121 is an SMYD3 inhibitor. It acts by impairing cancer cell growth.

Rewards