New Products

Catalog No. Product Name Product Information
A11293

AR-C155858

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
A12742

BAY 1000394 (Roniciclib)

BAY 1000394 is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity.
A13192

IWP-3

IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
A13041

PST-2744 (Istaroxime)

Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase).
A15263

Toceranib phosphate

Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR??.
A15264

Toll-like receptor modulator

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system.
A15265

Toremifene

Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.
A15266

Trenbolone

Trenbolone is a steroid used by veterinarians on livestock to increase muscle growth and appetite.
A15267

Tyrosine kinase inhibitor

Tyrosine-kinase inhibitor is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades.
A15268

Umeclidinium bromide

Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).
A15269

VAL-083

VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis.
A15270

Valaciclovir

Valacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B.
A15271

Vandetanib HCl

Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
A15272

Vandetanib trifluoroacetate

Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
A15273

Vc-MMAD

Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate.
A15274

VD2-D3

VD2-D3 is a deuterated form of vitamin D.
A15276

Vicriviroc maleate

Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1.
A15277

Vigabatrin

Vigabatrin is a structural analog of the inhibitory neurotransmitter ??-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
A15278

Vitamin D4

Vitamin D4 is the active analogue of Vitamin D.
A15279

VO-Ohpic trihydrate

VO-Ohpic trihydrate is an inhibitor of PTEN (phosphatase and tensin homologue deleted on chromosome 10).
A15280

Voreloxin Hydrochloride

Voreloxin Hcl is a small molecule and a naphthyridine analogue with antineoplastic activity; inhibitor of Topo II.
A15281

VTP-27999 2,2,2-trifluoroacetate

VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
A15282

WAY-100635 maleate salt

WAY-100635 maleate is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 - 0.12 nM for 5-HT.
A15283

XL-147 (Pilaralisib)

XL147 is a potent, orally bioavailable inhibitor of the class I PI3K family of lipid kinases.
A15284

YM-155 HCl

YM-155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.
A15285

Zaltidine

Zaltidine is a H2-receptor antagonist, which has the antisecretory action.
A15287

ZM323881

ZM323881 is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) with IC50 value of 2 nM.
A15289

Zosuquidar

Zosuquidar is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.
A15290

Acetyl-Calpastatin (184-210) (human)

Acetyl-Calpastatin (184-210) (human), selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 uM). Increases secretion of amyoid ??-protein (A??) 42, A??40 and A??42 ratio.
A15291

Ac-LEHD-AFC

Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
A15292

ARP 100

ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM.
A15293

ARP 101

ARP 101, selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively).
A15294

AZ 10417808

AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM).
A15296

Compound W

Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.
A15297

CP 471474

CP 471474, broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively).
A15298

DPPI 1c hydrochloride

DPPI 1c hydrochloride is a dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of CD26 (DPP 4), with an IC50 = 106 nM and little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 ??M.
A15299

Fumagillin

Fumagillin is a complex natural product antibiotic which covalently binds a key histidine residue of methionine aminopeptidase type II (MetAP-2), inhibiting endothelial cell proliferation and angiogenesis.
A15300

Ivachtin

Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
A15301

JLK 6

JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways.
A15303

MDL 28170

MDL 28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease which has been implicated in apoptosis of immune cells as well as neuronal cells.
A15304

MRK 560

MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
A15305

ONO 4817

ONO 4817 is used for testing effective treatment of MMP-related diseases.
A15306

PD 150606

PD 150606 is a cell-permeable, non-competitive, selective, non-peptide Ca2+ dependent calpain inhibitor for calpain-1 and for calpain-2 directed towards the Ca2+ binding sites of calpain.
A15307

PD 166793

PD166793 is a cell-permeable compound that strongly inhibits MMP (matrix metalloproteinase) -2 , -3, and -13, and weakly inhibits AMP deaminase, MMP-1, -7, -9, and -14.
A15308

PETCM

PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols.
A15309

PK 44 phosphate

PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) with an IC50 value of 15.8 nM.
A15311

Ro 32-3555

Ro 32-3555 is a potent, collagenase-selective MMP inhibitor .
A15312

SC 57461A

SC 57461A is a potent and competitive inhibitor of recombinant human leukotriene A4 hydrolase in vitro (Askonas et al., 2002).
A15313

SID 26681509

SID 26681509 is a reversible and potent human cathepsin L inhibitor. SID 26681509 displays no inhibitory activity of cathepsin G.
A15314

Spinorphin

Spinorphin is an endogenous factor that exhibits inhibitory effects on enkephalin-degrading enzymes.
A15315

SSR 69071

SSR 69071 is a high affinity, potent inhibitor of Neutrophil Elastase (human leukocyte elastase, HLE) (IC50 = 3.9 nM).
A15316

UK 370106

UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor .
A15317

WAY 170523

WAY 170523 has been reported to be a selective and potent inhibitor of MMP-13.
A15318

ZJ 43

ZJ 43 is a potent inhibitor of PSM and PSMAL (glutamate carboxypeptidase II and III).
A15319

Ac-IEPD-AFC

Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.
A15320

NVP DPP 728 dihydrochloride

NVP DPP 728 dihydrochloride is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively.
A15321

Vialinin A

Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis.
A15322

GI 254023X

GI 254023X is a selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17.
A15323

UK 356618

UK 356618 is a selective and potent inhibitor of MMP-3 that shows selectivity over a range of MMPs.
A15324

4-Chlorophenylguanidine hydrochloride

4-Chlorophenylguanidine hydrochloride is a potent and specific inhibitor of uPA (urokinase).
A15325

BC 11 hydrobromide

BC 11 hydrobromide, belective urokinase (uPA) inhibitor (IC50 = 8.2 ??M). Inhibits clot lysis with no effect on clot formation and exhibits no activity at 8 other uPA related enzymes.
A15327

Necrostatin 2 racemate

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
A15328

Necrostatin 2 S enantiomer

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
A15329

R18

R18, antagonist of 14.3.3 proteins (KD ??80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation.
A15330

2,3-DCPE hydrochloride

2,3 DCPE displays anticancer agent properties and induces ERK activation.
A15331

C 75

C 75 is an inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice.
A15332

CHM 1

CHM 1 is a potent, selective antitumor agent in human hepatocellular carcinoma in vitro.
A15333

Oncrasin 1

Oncrasin 1 is a proapoptotic substance. Induces abnormal nuclear aggregation of PKC?? and suppressing RNA transcription.
A15334

Plumbagin

Plumbagin, exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma; has antifungal, antiviral, and antibacterial action.
A15335

Bax channel blocker

Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 ??M).
A15336

Bax inhibitor peptide P5

Bax inhibitor peptide P5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.
A15338

Bax inhibitor peptide, negative control

Bax inhibitor peptide, negative control, negative control peptide for the Bax inhibitor peptides V5 and P5 , which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.
A15339

iMAC2

iMAC2 inhibits mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM).
A15340

Muristerone A

Muristerone A is a phytoecdysteroid analog of ecdysone which induces genes in mammalian cells and causes apoptosis in cells transfected with wild-type Bax.
A15342

DAPK Substrate Peptide

DAPK Substrate Peptide, synthetic peptide substrate for death associated protein kinase (DAPK) (Km = 9 ??M).
A15343

GRI 977143

GRI 977143, selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 ??M).
A15345

TLQP 21

TLQP 21, VGF-derived peptide; spans residues 556-576 of the precursor sequence.
A15346

CP 31398 dihydrochloride

CP 31398 dihydrochloride, p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.
A15347

HLI 373

HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription.
A15348

MIRA-1

MIRA-1 restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA.
A15349

NSC 146109 hydrochloride

NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription.
A15350

PhiKan 083

PhiKan 083, p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions.
A15351

RETRA hydrochloride

RETRA hydrochloride is an antitumor agent which inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and iin vivo.
A15352

SJ 172550

SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
A15353

WR 1065

WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure.
A15354

KD 5170

KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.
A15355

NCH 51

NCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM.
A15356

NSC 3852

NSC 3852 is an HDAC (histone deacetylase) inhibitor.
A15357

TC-H 106

TC-H 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases).
A15358

Chetomin

Chetomin is reported to be an antibiotic metabolite of Chaetomium spp. which contains bacteriostatic effects on Gram-positive bacteria.
A15359

KC7F2

KC7F2 is an inhibitor of HIF-1?? protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K).
A15360

ML 228

ML-228 is an activator of the HIF signaling pathway, as demonstrated by HIF response element (HRE) reporter assay, HIF-1?? nuclear translocation assay, and increased VEGF expression.
A15361

1,2,3,4,5,6-Hexabromocyclohexane

1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.
A15362

Cercosporamide

Cercosporamide, an usnic amide, was originally identified in Cercosporidium henningsii as a host-selective phytotoxin and broad-spectrum antifungal agent and is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2; IC50 = 11 nM), JAK3 (IC50 = 31), and Mnk1 (IC50 = 116 nM).
A15363

Cucurbitacin I

Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells.
A15364

SD 1008

SD 1008 is reported to be a JAK2/STAT3 signaling pathway inhibitor which additionally inhibits Src. SD 1008 is noted to induce apoptosis in cell lines that express constitutively active tyrosine-phosphorylated STAT3.
A15365

TCS 21311

TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively).
A15366

ZM 449829

JAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site.
A15367

UNC 926 hydrochloride

UNC 926 is a methyl lysine reader domain inhibitor.
A15368

PIM-1 Inhibitor 2

PIM-1 inhibitor 2 is a potent Pim-1 kinase inhibitor (Ki = 91 nM).
A15370

4-HQN

4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins.
A15371

BYK 204165

BYK204165 is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1).
A15372

BYK 49187

BYK 49187, PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively).
A15373

DR 2313

PARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor.
A15374

EB 47

EB 47 is a potent inhibitor of PARP1 with IC50 of 45 nM.
A15375

NU 1025

NU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells.
A15376

Calcineurin Autoinhibitory Peptide

Calcineurin inhibitory peptide is a selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 ??M). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).
A15377

Ceramide

Ceramide is a ceramide shown to be a potent modulator of proliferation and differentiation, used as a tool for studying the complex signaling associated with the ceramides.
A15378

DL-AP3

DL-AP3, a racemic preparation of D-AP3 and L-AP3, is an inhibitor of phosphoserine phosphatase and an antagonist of the metabotropic glutamate receptor (mGluR), blocking phosphoinositide turnover mediated by the mGluR.
A15379

Fumonisin B1

Fumonisin B1 is a fungal metabolite produced by Fusarium moniliforme, that has been shown to inhibit protein serine/threonine phosphatases (PP1, PP2A, PP2B, PP2C, and PP5/T/K/H), and is most effective with PP5.
A15380

INCA-6

INCA-6 is a potent and selective inhibitor of calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling.
A15381

NFAT Inhibitor

NFAT Inhibitor, selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT).
A15382

Alexidine dihydrochloride

Alexidine is an alkyl bis(biguanide) antiseptic which has been used in mouthwashes to eliminate plaque forming microorganisms.
A15383

BVT 948

BVT 948 is a non-competitive PTP (protein tyrosine phosphatase) inhibitor.
A15384

NSC 87877

NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1).
A15385

Mithramycin A

Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-?? and Fas-ligand induced apoptosis.
A15386

Thiolutin

Thiolutin is an RNA polymerase inhibitor, and a sulfur-based microbial antibiotic generated by Streptomyces sp.
A15387

TCS HDAC6 20b

TCS HDAC6 20b, selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol. Also inhibits growth of MCF-7 cells stimulated by estrogen.
A15388

UNC 0224

UNC0224 is a potent and selective G9a inhibitor with IC50 of 15 nM in in the G9a Thioglo assay.
A15389

NSC 33994

NSC 33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies.
A15390

TCS 401

TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).
A15392

Boc-D-FMK

BOC-D-FMK is a Novel inhibitor of Caspase-3.
A15393

Ophiopogonin D'

Ophiopogonin D', extracted from Ophiopogon japonicus (Thunb.) Ker-Gawl. dried tuberous roots.
A15394

Mogroside IVe

Mogroside Ive, Extracted from Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang dried fruit .
A15395

Diosmetin-7-O-beta-D-glucopyranoside

Diosmetin-7-O-beta-D-glucopyranoside, extracted from Chrysanthemum dried flowers.
A15396

Quercetin-7-O-beta-D-glucopyranoside

Quercetin-7-O-beta-D-glucopyranoside, extracted from Sophora flavescens Ait.
A15397

Isorhamnetin 3-O-beta-D-Glucoside

Isorhamnetin-3-O-beta-D-Glucoside, extracted from dried whole herb of Filifolium Kitam. Filifolium sibiricum (L.) Kitam..
A15398

CiMigenol 3-beta-D-xylopyranoside

CiMigenol 3-beta-D-xylopyranoside, extracted from Beesia calthifolia( Maxim. ) Ulhr. Rhizome.
A15399

alpha-hederin

Alpha-hederin, a saponin extracted from Hedera helix.
A15400

alpha-Boswellic acid

alpha-Boswellic acid, extracted from Boswellia sacra.
A15401

Rhein-8-O-beta-D-glucopyranoside

Rhein-8-O-beta-D-glucopyranoside, extracted from Rheum palmatum L. rhizome.
A15402

Chrysophanol-8-O-beta-D-glucopyranoside

Chrysophanol-8-O-beta-D-glucopyranoside, extracted from Rheum palmatum L?? rhizome.
A15403

N-Methylcytisine

N-methylcytisine, a selective ligand of nicotinic receptors of acetylcholine in the CNS.
A15404

Apigenin-7-O-beta-D-glucopyranoside

Apigenin-7-O-beta-D-glucopyranoside, extracted from Andrographis paniculata Nees. dried parts on the ground.
A15405

Cucurbitacin IIb

Cucurbitacin Iib, extracted from Hemsleya amabilis Diels root tuber.
A15406

Cucurbitacin S

Cucurbitacin S, extracted from Hemsleya amabilis Diels root tuber.
A15407

Cimigenol-3-O-alpha-L-arabinoside

Cimigenol-3-O-alpha-L-arabinoside is extracted from Cimicifuga foetida L. dried rhizome.
A15408

20(R)-Ginsenoside Rh2

20(R)-Ginsenoside Rh2 is a matrix metalloproteinase (MMP) inhibitor that acts as a cell antiproliferator.
A15409

2''-O-Galloylhyperin

2''-O-Galloylhyperin, extracted from whole dried herb of pyrola wintergreen and Pyrola decorata H.Andres.
A15410

Magnoflorine iodide

Magnoflorine iodide is extracted from Thalictrum dasycarpum Fisch.et Hall.
A15412

beta-Eudesmol

beta-Eudesmol is extracted from eucalyptus oil.
A15413

alpha-Cyperone

alpha-Cyperone is extracted from Cyperus rotundus L. dried rhizome.
A15414

Amyloid b-peptide (42-1) (human)

Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide.
A15415

Amyloid b-Peptide (10-20) (human)

Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
A15417

Amyloid b-Peptide (12-28) (human)

Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins.
A15418

Amyloid b-Peptide (1-40) (human)

Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP).
A15419

Amyloid b-peptide (1-40) (rat)

Amyloid b-peptide (1-40) (rat)
A15420

Amyloid b-peptide (1-42) (rat)

Amyloid b-peptide (1-42) (rat)
A15421

Amyloid b-Peptide (1-43) (human)

Amyloid b-Peptide (1-43) (human), amyloid ?? peptide fragment. Highly toxic, showing higher neurotoxicity compared to A??40 and A??42.
A15422

beta-Pompilidotoxin

beta-Pompilidotoxin is a peptide with the sequence H2N-Arg.
A15423

beta-Amyloid (1-11)

Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.
A15424

Amyloid b-Protein (1-15)

Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.
A15425

b-Lipotropin (1-10), porcine

Beta-lipotropin (beta-LPH) was found to contain within its C-terminal sequence the primary structure of these peptides.
A15426

beta-Interleukin I (163-171), human

beta-Interleukin I (163-171), human, a peptide. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes).
A15427

Clasto-Lactacystin b-lactone

Clasto-lactacystin b-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive b-lactone.
A15428

Zidovudine

Zidovudine is a nucleoside analog reverse-transcriptase inhibitor (NRTI), a type of antiretroviral drug used for the treatment of HIV/AIDS infection. Azidothymidine decreases CRISPR-mediated homology directed repair (HDR) efficiency.
A15429

6b-Hydroxy-21-desacetyl Deflazacort

N/A
A15430

PI4KIII beta inhibitor 3

PI4KIII beta inhibitor 3 is a novel and high effective PI4KIII beta inhibitor with IC50 of 5.7 nM.
A14351

Isatoribine

Isatoribine is a novel guanosine analogue showing immunostimulatory activity both in vivo and in vitro.
A14987

ALK inhibitor 1

ALK inhibitor 1 is a novel and selective inhibitor for the ALK kinase.
A14988

ALK inhibitor 2

ALK inhibitor 2 is a novel and selective inhibitor for the ALK kinase.
A14989

Alosetron Hydrochloride

Alosetron is s Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
A14990

Alvespimycin

Alvespimycin is a selective Hsp90 inhibitor with a GI50 of 53 nM.
A14991

Alvimopan dihydrate

Alvimopan dihydrate(LY 246736, ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.
A14992

Alvimopan monohydrate

Alvimopan monohydrate is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.
A14994

AM679

AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.
A14995

Amadacycline

Amadacycline is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome.
A14996

Amadacycline methanesulfonate

Amadacycline methanesulfonate is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome.
A14997

AMD-070 HCl

AMD-070 hydrochloride is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, inhibit the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
A14998

Amineptine

Amineptine is a tricyclic antidepressant drug selectively blocking dopamine uptake, on 3H-imipramine binding, which was investigated in platelets of major depressed patients in conjunction with changes in clinical state.
A14999

AN-2690

AN-2690, an antifungal agent with activity against Trichophyton species, in a topical solution formulation, for the potential treatment of onychomycosis.
A15000

Anamorelin Fumarate

Anamorelin fumarate is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia.
A15001

ARRY-520 R enantiomer

ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
A15002

Asenapine HCl

Asenapine hydrochloride inhibits adrenergic receptor (??1, ??2A, ??2B, ??2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
A15003

AST 487

AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret.
A15004

AT-101

AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM.
A15005

AT7519 trifluoroacetate

AT7519 trifluoroacetate is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM, less potent to CDK3 and little active to CDK7.
A15006

AT7867 2HCl

AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family.
A15007

Atrasentan HCl

Atrasentan hydrochloride is an endothelin antagonist receptor (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
A15008

AVL-292 benzenesulfonate

AVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM, >1400-fold selectivity over the other kinases assayed.
A15009

Azaphen dihydrochloride monohydrate

Azaphen is a potent inhibitor of the reuptake of serotonin.
A15010

Azathramycin

Azithromycin, derived from erythromycin, is a antibiotic. Azithromycin binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA.
A15011

AZD1152

AZD1152 is a pro-drug that rapidly undergoes phosphatase-mediated cleavage in serum to release barasertib-hQPA, a selective Aurora B kinase inhibitor that has shown preliminary activity in clinical studies of patients with acute myeloid leukemia (AML).
A15012

AZD7687

AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1).
A15014

Baricitinib phosphate

Baricitinib phosphate is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2.
A15015

Bavisant dihydrochloride

Bavisant dihydrochloride is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
A15016

Bavisant dihydrochloride hydrate

Bavisant dihydrochloride hydrate is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
A12730

Epoxomicin

Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.
A12881

BX-517

BX-517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).
A12947

UNC0638

UNC0638 is an inhibitor of protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets.
A12998

Laninamivir (CS-8958)

Laninamivir is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B.
A13029

Radotinib (IY-5511)

Radotinib is a novel and selective Bcl-Abl tyrosine kinase inhibitor
A15556

ML204

ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
A15760

SU10944

SU10944 is a small molecule kinase inhibitor of VEGFR that inhibits neovascularization and permeability, and is distributed to the eye upon systemic delivery.
A15762

BI-847325

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
A15766

Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC peptide linker.
A15767

NU2058

NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1.
A15769

SBC-115076

SBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases.
A15771

Oritavancin (LY333328)

Oritavancin is a novel semisynthetic glycopeptide antibiotics. On August 6, 2014, the FDA approved oritavancin for treatment of skin infections. Oritavancin possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible Gram-positive bacteria, including Staphylococcus aureus, MRSA, enterococci, and streptococci.
A15772

GS-7340

GS-7340 is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.
A15773

Cardiogenol C hydrochloride

Cardiogenol C hydrochloride is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.
A15774

ISX-9

ISX-9 is a small molecule inducer of adult neural stem cell differentiation.
A15775

NIBR189

NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).
A15777

JH-II-127

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.
A15778

Mavatrep

Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 ??M) of CYP isoforms 3A4, 1A2, and 2D6.
A15779

CC-115

CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
A15781

UF010

UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 ??M, 0.1 ??M, 0.5 ??M and 1.5 ??M for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.
A15782

Acotiamide hydrochloride trihydrate

Acotiamide is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.
A15783

Isavuconazole

Isavuconazole is the active component of the new azole antifungal agent BAL8557, exhibits MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata.
A15784

OPC21268

OPC21268 is a non-peptide AVP Receptor V (Vasopressin Receptor) antagonist that shows 1000-fold selectivity for V1 receptors over V2 receptors.
A15785

7ACC2

7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.
A15786

NVP-TNKS656

NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
A15787

Propyzamide

Propyzamide is usually used as a selective herbicide.
A15788

Ascomycin

Ascomycin is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It has been researched for the treatment of autoimmune diseases and skin diseases, and to prevent rejection after an organ transplant.
A15770

Ursodeoxycholic acid

Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary diseases.
A15790

L189

L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 ??M.
A15791

CGS19755

CGS 19755 (cis-4-phosphonomethyl-2-piperidine carboxylic acid) was found to be a potent, stereospecific inhibitor of N-methyl-D-aspartate (NMDA)-evoked, but not KCl-evoked, [3H] acetylcholine release from slices of the rat striatum.
A15792

BMS-817378

BMS-817378 is a novel prodrug of the dual Met/VEGFR-2 inhibitor BMS-794833.
A15793

JNJ-42041935

JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
A15796

L-778123 HCl

L-778123 HCl is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.
A15798

SW033291

SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
A15800

SM-164

SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.
A12584

ON123300

ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as ??-type platelet-derived growth factor receptor (PDGFR??).
A12585

MS023

MS023 is a potent inihbitor of PRMTs 1,3,4,6,and 8 (IC50 = 30, 119, 83, 8, and 8 nM, respectively), which are responsible for asymmetric dimethylation of arginine residues.
A11538

Pardoprunox HCl (SLV-308)

Pardoprunox is an antiparkinsonian drug currently under development by Solvay for the treatment of Parkinson's disease.
A12194

AL082D06

AL082D06 is a nonsteroidal glucocorticoid receptor antagonist.
A12386

Eliglustat

Eliglustat is a specific and potent inhibitor of glucosylceramide synthase.
A12390

JZL195

JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.
A12405

NS6180

NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation.
A12595

BIO-32546

N/A
A12937

(R)-P7C3-Ome

(R)-P7C3-Ome is a methoxy derivative of parent compound P7C3, an aminopropyl carbazole that exhibits antidepressant and neuroprotective activities.
A12946

Eliprodil

Eliprodil is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).
A13196

BD-1047 2HBr

BD-1047 2HBr is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
A13199

Trovirdine

Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.
A13216

RO462005

RO462005 is an endothelin receptor selective agonist.
A13405

HDAC inhibitor

N/A
A16069

Versipelostatin

Versipelostatin is a novel GRP78/Bip molecular chaperone down-regulator of microbial origin that was isolated from the metabolite of Streptomyces versipellis strain 4083-SVS6.