Nutlin 3b

Catalog No.: A11502

MDM2 inhibitor

Nutlin 3b Chemical Structure

CAS NO. 675576-97-3

Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
25 mg
$280.00
50 mg
$500.00
10mM * 1mL in DMSO
$199.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
Targets
Mdm2
13.6 μM
In vitro DMSO 100 mg/mL (171.97 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (171.97 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.2 mL 85.99 mL 171.97 mL
0.5 mM 3.44 mL 17.2 mL 34.39 mL
1 mM 1.72 mL 8.6 mL 17.2 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 581.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11502
Actions Inhibitor
M. Wt 581.49
Formula C30H30Cl2N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 675576-97-3
Synonyms (+)-Nutlin-3, Nutlin-3b
SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=N[[email protected]@H]([[email protected]@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

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