Catalog No.: A10658

IGF-1R inhibitor


NVP-ADW742 Chemical Structure

CAS NO. 475488-23-4

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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  • Kazuya Takayama, .et al. Leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1 activation are required for position-dependent regeneration, Sci Rep, 2018, 8: 8278 PMID: 29844341
  • Kentaro Hirose, .et al. Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins, BMC Dev Biol, 2014, 14: 42. PMID: 25480380

Biological Activity

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.
0.17 μM
In vitro DMSO Warmed: 9 mg/mL (19.84 mM)
Water Insoluble
Ethanol 3 mg/mL (6.61 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.05 mL 110.23 mL 220.46 mL
0.5 mM 4.41 mL 22.05 mL 44.09 mL
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL

*The above data is based on the productmolecular weight 453.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10658
Actions Inhibitor
CAS No. 475488-23-4
Formula C28H31N5O
M. Wt 453.6
Purity >98%
Synonyms NVPADW742, ADW742, ADW-742, GSK 552602A

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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