Linsitinib (OSI-906)

OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).
Grouped product items
Product Name Price Stock Qty
Linsitinib (OSI-906) 5mg
$58.00
In stock
Linsitinib (OSI-906) 10mg
$82.00
In stock
Linsitinib (OSI-906) 50mg
$180.00
In stock
Linsitinib (OSI-906) 100mg
$250.00
In stock
Linsitinib (OSI-906) 10mM * 1mL in DMSO
$50.00
In stock
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Adooq Products cited in reputable paper
Adooq's Linsitinib (OSI-906) has been cited by 4 publications
  • Masao Kakoki, .et al. , Communications Biology, 2021, 4:775
  • Nakamura T, .et al. , J Med Food, 2018, Jul;21(7):701-708 PMID: 29583066
  • Tzeng SF, .et al. , FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
  • Takata N, .et al. , In Vitro Cell Dev Biol Anim., 2016, May;52(5):607-15 PMID: 26956358
  • Biological Activity
    Discription OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).
    Targets
    Target Value
    Product Information
    Catalog Num A11053
    Formula C26H23N5O
    Molecular Weight 421.5
    CAS Number 867160-71-2
    SMILES CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
    Synonyms OSI906, linsitinib
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 80 mg/mL (189.8 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 5.93 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 23.72 mL 118.62 mL 237.25 mL
    0.5 mM 4.74 mL 23.72 mL 47.45 mL
    1 mM 2.37 mL 11.86 mL 23.72 mL
    5 mM 0.47 mL 2.37 mL 4.74 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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