OSI-906

Name: OSI-906
Brand: Adooq Bioscience
SKU: A11053
Rating: 100 (4 reviews)

Catalog No.: A11053

IGF-1R inhibitor

Product Citations (4)

OSI-906 Chemical Structure

CAS NO. 867160-71-2

OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).

Availability: In stock

Package	Price	Qty
5 mg	$58.00
10 mg	$82.00
50 mg	$180.00
100 mg	$250.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq OSI-906

Masao Kakoki, .et al. Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling, Communications Biology, 2021, 4:775
Nakamura T, .et al. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production, J Med Food, 2018, Jul;21(7):701-708 PMID: 29583066
Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
Takata N, .et al. IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro, In Vitro Cell Dev Biol Anim., 2016, May;52(5):607-15 PMID: 26956358

Biological Activity

OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).

Targets

Target	Value
IGF-1R	IC50: 35nM
Insulin Receptor	IC50: 75nM
IRR	IC50: 75nM
Abl	IC50: >10μM
ALK	IC50: >10μM
BTK	IC50: >10μM
EGFR	IC50: >10μM
EphA1	IC50: >10μM
EphB1	IC50: >10μM
FES	IC50: >10μM
FGFR1	IC50: >10μM
FGFR2	IC50: >10μM
Fyn	IC50: >10μM
PKA	IC50: >10μM
PKCα	IC50: >10μM
ROCK1	IC50: >10μM
IRAK4	IC50: >10μM
JAK2	IC50: >10μM
KDR	IC50: >10μM
LCK	IC50: >10μM
LynA	IC50: >10μM
LynB	IC50: >10μM
Met	IC50: >10μM
TrkA	IC50: >10μM
PDGFRα	IC50: >10μM
PDGFRβ	IC50: >10μM
FAK	IC50: >10μM
BRK	IC50: >10μM
RET	IC50: >10μM
Pim1	IC50: >10μM
CDK1	IC50: >10μM
DYRK2	IC50: >10μM
Src	IC50: >10μM
Tek	IC50: >10μM
MEK1	IC50: >10μM
Akt1	IC50: >10μM
Akt2	IC50: >10μM
AuroraA	IC50: >10μM
AuroraB	IC50: >10μM
PDK-1	IC50: >10μM
PLK1	IC50: >10μM
p38α	IC50: >10μM
ERK1	IC50: >10μM
GSK-3α	IC50: >10μM
p70S6K	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	80 mg/mL (189.8 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	5.93 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.72 mL	118.62 mL	237.25 mL
0.5 mM	4.74 mL	23.72 mL	47.45 mL
1 mM	2.37 mL	11.86 mL	23.72 mL
5 mM	0.47 mL	2.37 mL	4.74 mL

*The above data is based on the productmolecular weight 421.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11053
Actions	Inhibitor
CAS No.	867160-71-2
Formula	C26H23N5O
M. Wt	421.5
Purity	>98%
Synonyms	OSI906, linsitinib
SMILES	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.