Catalog No.: A11053

IGF-1R inhibitor


OSI-906 Chemical Structure

CAS NO. 867160-71-2

OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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  • Masao Kakoki, .et al. Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling, Communications Biology, 2021, 4:775
  • Nakamura T, .et al. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production, J Med Food, 2018, Jul;21(7):701-708 PMID: 29583066
  • Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
  • Takata N, .et al. IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro, In Vitro Cell Dev Biol Anim., 2016, May;52(5):607-15 PMID: 26956358

Biological Activity

OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).
Target Value
IGF-1RIC50: 35nM
Insulin ReceptorIC50: 75nM
IRRIC50: 75nM
AblIC50: >10μM
ALKIC50: >10μM
BTKIC50: >10μM
EGFRIC50: >10μM
EphA1IC50: >10μM
EphB1IC50: >10μM
FESIC50: >10μM
FGFR1IC50: >10μM
FGFR2IC50: >10μM
FynIC50: >10μM
PKAIC50: >10μM
PKCαIC50: >10μM
ROCK1IC50: >10μM
IRAK4IC50: >10μM
JAK2IC50: >10μM
KDRIC50: >10μM
LCKIC50: >10μM
LynAIC50: >10μM
LynBIC50: >10μM
MetIC50: >10μM
TrkAIC50: >10μM
PDGFRαIC50: >10μM
PDGFRβIC50: >10μM
FAKIC50: >10μM
BRKIC50: >10μM
RETIC50: >10μM
Pim1IC50: >10μM
CDK1IC50: >10μM
DYRK2IC50: >10μM
SrcIC50: >10μM
TekIC50: >10μM
MEK1IC50: >10μM
Akt1IC50: >10μM
Akt2IC50: >10μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
PDK-1IC50: >10μM
PLK1IC50: >10μM
p38αIC50: >10μM
ERK1IC50: >10μM
GSK-3αIC50: >10μM
p70S6KIC50: >10μM
In vitro (25°C) DMSO 80 mg/mL (189.8 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 5.93 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.72 mL 118.62 mL 237.25 mL
0.5 mM 4.74 mL 23.72 mL 47.45 mL
1 mM 2.37 mL 11.86 mL 23.72 mL
5 mM 0.47 mL 2.37 mL 4.74 mL

*The above data is based on the productmolecular weight 421.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11053
Actions Inhibitor
CAS No. 867160-71-2
Formula C26H23N5O
M. Wt 421.5
Purity >98%
Synonyms OSI906, linsitinib

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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