OSI-906

Catalog No.: A11053

IGF-1R inhibitor

OSI-906

OSI-906 Chemical Structure

CAS NO. 867160-71-2

OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $50.00

Special Price $45.00

10 mg

Regular Price: $70.00

Special Price $63.00

50 mg

Regular Price: $150.00

Special Price $135.00

100 mg

Regular Price: $210.00

Special Price $189.00

10mM * 1mL in DMSO

Regular Price: $50.00

Special Price $45.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).
Targets
Target Value
IGF-1RIC50: 35nM
Insulin ReceptorIC50: 75nM
IRRIC50: 75nM
AblIC50: >10μM
ALKIC50: >10μM
BTKIC50: >10μM
EGFRIC50: >10μM
EphA1IC50: >10μM
EphB1IC50: >10μM
FESIC50: >10μM
FGFR1IC50: >10μM
FGFR2IC50: >10μM
FynIC50: >10μM
PKAIC50: >10μM
PKCαIC50: >10μM
ROCK1IC50: >10μM
IRAK4IC50: >10μM
JAK2IC50: >10μM
KDRIC50: >10μM
LCKIC50: >10μM
LynAIC50: >10μM
LynBIC50: >10μM
MetIC50: >10μM
TrkAIC50: >10μM
PDGFRαIC50: >10μM
PDGFRβIC50: >10μM
FAKIC50: >10μM
BRKIC50: >10μM
RETIC50: >10μM
Pim1IC50: >10μM
CDK1IC50: >10μM
DYRK2IC50: >10μM
SrcIC50: >10μM
TekIC50: >10μM
MEK1IC50: >10μM
Akt1IC50: >10μM
Akt2IC50: >10μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
PDK-1IC50: >10μM
PLK1IC50: >10μM
p38αIC50: >10μM
ERK1IC50: >10μM
GSK-3αIC50: >10μM
p70S6KIC50: >10μM
In vitro (25°C) DMSO 84 mg/mL (199.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.72 mL 118.62 mL 237.25 mL
0.5 mM 4.74 mL 23.72 mL 47.45 mL
1 mM 2.37 mL 11.86 mL 23.72 mL
5 mM 0.47 mL 2.37 mL 4.74 mL

*The above data is based on the productmolecular weight 421.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11053
Actions Inhibitor
M. Wt 421.5
Formula C26H23N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 867160-71-2
Synonyms OSI906, linsitinib
SMILES CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O

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