P 22077

Catalog No.: A12933

USP7 inhibitor

P 22077

P 22077 Chemical Structure

CAS NO. 1247819-59-5

P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 μM) and the closely related deubiquitinase (DUB) USP47.

Availability: In stock

Package Price Qty
10 mg
$70.00
25 mg
$140.00
50 mg
$220.00
100 mg
$380.00
10mM * 1mL in DMSO
$97.00
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Biological Activity

P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 μM) and the closely related deubiquitinase (DUB) USP47.
Targets
Target Value
USP7EC508.6μM
USP47EC508.74μM
USP2coreEC50>50μM
USP4EC50>50μM
USP5EC50>50μM
USP8EC50>50μM
USP15EC50>50μM
USP20EC50>50μM
USP28EC50>50μM
JOSD2EC50>50μM
UCH-L1EC50>50μM
UCH-L3EC50>50μM
UCH-L5EC50>50μM
DEN1EC50>50μM
PlproEC50>50μM
SENP6coreEC50>50μM
PLA2EC50>50μM
Calpain1EC50>50μM
CT-LEC50>50μM
CathepsinDEC50>50μM
MMP13EC50>50μM
TrypsinEC50>50μM
In vitro (25°C) DMSO 57 mg/mL (180.76 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.71 mL 158.57 mL 317.14 mL
0.5 mM 6.34 mL 31.71 mL 63.43 mL
1 mM 3.17 mL 15.86 mL 31.71 mL
5 mM 0.63 mL 3.17 mL 6.34 mL

*The above data is based on the productmolecular weight 315.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12933
Actions Inhibitor
CAS No. 1247819-59-5
Formula C12H7F2NO3S2
M. Wt 315.32
Purity >98%
Synonyms P22077
SMILES CC(=O)C1=CC(=C(S1)SC2=C(C=C(C=C2)F)F)[N+](=O)[O-]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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