p38-MAPK

Catalog No.Inhibitor Name p38 MAPKp38αp38βOther
A10824SB203580
*
PKB
A10148Doramapimod
****
A10823SB202190
**
**
A10545LY2228820
****
A10982VX-702
***
A11078PH-797804
***
*
A10983VX-745
***
*
A11582TAK-715
****
*
A11562SB239063
**
**
A12526Losmapimod
***
***
A11321Skepinone-L
****
A10895Pexmetinib
Tie-2
A10970AMG 548
****
***
A11221PD 169316
**
A11563 SD-06
*
A12408ML-3043
*
IL-1β, TNF-α
A12770Talmapimod (SCIO-469)
***
A13551Pamapimod (R-1503)
***
*
A13552RWJ 67657
*
*
A13563BMS-582949
***
A13678SB-242235
***
A16015AL 8697
****
A16035SX 011
***
A16038JX 401
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

33 Item(s)

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  1. SB-242235

    Catalog No. A13678
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    p38 MAPK inhibitor
    SB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases. Learn More
  2. RWJ-67657

    Catalog No. A13552
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    p38 MAPK inhibitor
    RWJ-67657 is a potent p38 MAPK inhibitor. Learn More
  3. BMS-582949

    Catalog No. A13563
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    p38 MAPK inhibitor
    BMS-582949 Is a Dual Action p38 Kinase Inhibitor Well Suited To Avoid Resistance Mechanisms That Increase p38 Activation in Cells. Learn More
  4. Pexmetinib (ARRY-614)

    Catalog No. A10895
    p38 MAPK inhibitor
    Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase. Learn More
  5. AMG 548

    Catalog No. A10970
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    p38 MAPK inhibitor
    AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα. Learn More
  6. SKF 86002 Dihydrochloride

    Catalog No. A11101
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    p38 MAPK inhibitor
    SKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 uM). Learn More
  7. SD-06

    Catalog No. A11563
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    p38 MAPK inhibitor
    SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). Learn More
  8. AL 8697

    Catalog No. A16015
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    p38 MAPK inhibitor
    AL-8697 is a selective p38 MAPK(mitogen-activated protein Kinase) inhibitor, which is also named P38α inhibitor. It has the function of inhibiting the activity of P38 MAPK. Learn More
  9. SX 011

    Catalog No. A16035
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    P38 MAPK inhibitor
    SX 011 is a selective p38α, p38β and JNK-2 inhibitor. Reported to display no significant activity at p38γ, p38δ, ERK-2 and JNK-1. Learn More
  10. EO 1428

    Catalog No. A16037
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    P38 MAPK inhibitor
    EO 1428 is a synthetic 4-aminobenzophenone small molecule identified in an optimization study for inhibitors of p38 MAP kinase. Learn More
  11. JX 401

    Catalog No. A16038
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    P38 MAPK inhibitor
    JX 401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). Learn More
  12. SB 706504

    Catalog No. A16055
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    p38 MAPK inhibitor
    SB 706504 is a p38 MAPK inhibitor, preventing LPS-induced transcription of a range of chemokineis and cytokines in chronic obstructive pulmonary disease monocyte derived macrophages. Learn More
  13. DBM 1285 dihydrochloride

    Catalog No. A16058
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    p38 MAPK inhibitor
    DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. Learn More
  14. CMPD-1

    Catalog No. A16040
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    p38 MAPK Inhibitor
    CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Learn More
  15. Dilmapimod

    Catalog No. A13553
    p38 MAPK inhibitor
    Dilmapimod is p38 MAPK inhibitor. Learn More
  16. Pamapimod (R-1503)

    Catalog No. A13551
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    p38 MAPK inhibitor
    Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor. Learn More
  17. SB 203580

    Catalog No. A10824
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    p38 MAPK inhibitor
    SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. Learn More
  18. Losmapimod (GW856553X)

    Catalog No. A12526
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    p38 MAPK inhibitor
    Losmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases. Learn More
  19. Doramapimod (BIRB-796)

    Catalog No. A10148
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    p38 MAPK inhibitor
    Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines. Learn More
  20. SB 202190

    Catalog No. A10823
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    p38 MAPK Inhibitor
    SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Learn More
  21. LY2228820 (Ralimetinib)

    Catalog No. A10545
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    p38 MAPK inhibitor
    LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. Learn More
  22. VX-702

    Catalog No. A10982
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    p38 MAPK inhibitor
    VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM). Learn More
  23. VX-745

    Catalog No. A10983
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    p38 MAPK inhibitor
    VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ . Learn More
  24. PH-797804

    Catalog No. A11078
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    p38 MAPK inhibitor
    PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase. Learn More
  25. Asiatic acid

    Catalog No. A10092
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    Anti-inflammatory agent

    Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.

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  26. PD 169316

    Catalog No. A11221
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    p38 MAPK inhibitor
    PD 169316 (PD169316) is a selective inhibitor of p38 MAPK.1 that inhibits p38 MAPK with an IC50 of 89 nM. Learn More
  27. Skepinone-L

    Catalog No. A11321
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  28. Asiaticoside

    Catalog No. A12021
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    Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns. Learn More
  29. SB 239063

    Catalog No. A11562
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    p38 MAPK inhibitor
    SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo. Learn More
  30. TAK-715

    Catalog No. A11582
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    p38 MAPK inhibitor
    TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε. Learn More
  31. Talmapimod (SCIO-469)

    Catalog No. A12770
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    p38 MAPK inhibitor
    Talmapimod (SCIO-469) is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Learn More
  32. ML-3043

    Catalog No. A12408
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    p38 MAPK inhibitor
    ML-3043 is a p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively). Learn More
  33. TA-01

    Catalog No. A16236
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    CK inhibitor
    TA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively). Learn More

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