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$0.00 p38-MAPK
| Catalog No. | Inhibitor Name | p38 MAPK | p38α | p38β | Other |
|---|---|---|---|---|---|
| A10824 | SB203580 | * | PKB | ||
| A10148 | Doramapimod | **** | |||
| A10823 | SB202190 | ** | ** | ||
| A10545 | LY2228820 | **** | |||
| A10982 | VX-702 | *** | |||
| A11078 | PH-797804 | *** | * | ||
| A10983 | VX-745 | *** | * | ||
| A11582 | TAK-715 | **** | * | ||
| A11562 | SB239063 | ** | ** | ||
| A12526 | Losmapimod | *** | *** | ||
| A11321 | Skepinone-L | **** | |||
| A10895 | Pexmetinib | Tie-2 | |||
| A10970 | AMG 548 | **** | *** | ||
| A11221 | PD 169316 | ** | |||
| A11563 | SD-06 | * | |||
| A12408 | ML-3043 | * | IL-1β, TNF-α | ||
| A12770 | Talmapimod (SCIO-469) | *** | |||
| A13551 | Pamapimod (R-1503) | *** | * | ||
| A13552 | RWJ 67657 | * | * | ||
| A13563 | BMS-582949 | *** | |||
| A13678 | SB-242235 | *** | |||
| A16015 | AL 8697 | **** | |||
| A16035 | SX 011 | *** | |||
| A16038 | JX 401 | ** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
43 Item(s)
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Doramapimod (BIRB-796)
Catalog No. A10148 p38 MAPK inhibitorDoramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines. Learn More -
DBM 1285 dihydrochloride
Catalog No. A16058 p38 MAPK inhibitorDBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. Learn More -
SB 706504
Catalog No. A16055 p38 MAPK inhibitorSB 706504 is a p38 MAPK inhibitor, preventing LPS-induced transcription of a range of chemokineis and cytokines in chronic obstructive pulmonary disease monocyte derived macrophages. Learn More -
JX 401
Catalog No. A16038 P38 MAPK inhibitorJX 401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). Learn More -
EO 1428
Catalog No. A16037 P38 MAPK inhibitorEO 1428 is a synthetic 4-aminobenzophenone small molecule identified in an optimization study for inhibitors of p38 MAP kinase. Learn More -
SX 011
Catalog No. A16035 P38 MAPK inhibitorSX 011 is a selective p38α, p38β and JNK-2 inhibitor. Reported to display no significant activity at p38γ, p38δ, ERK-2 and JNK-1. Learn More -
AL 8697
Catalog No. A16015 p38 MAPK inhibitorAL-8697 is a selective p38 MAPK(mitogen-activated protein Kinase) inhibitor, which is also named P38α inhibitor. It has the function of inhibiting the activity of P38 MAPK. Learn More -
SD-06
Catalog No. A11563 p38 MAPK inhibitorSD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). Learn More -
SKF 86002 Dihydrochloride
Catalog No. A11101 p38 MAPK inhibitorSKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 uM). Learn More -
AMG 548
Catalog No. A10970 p38 MAPK inhibitorAMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα. Learn More -
Pexmetinib (ARRY-614)
Catalog No. A10895 p38 MAPK inhibitorPexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase. Learn More -
BMS-582949
Catalog No. A13563 p38 MAPK inhibitorBMS-582949 Is a Dual Action p38 Kinase Inhibitor Well Suited To Avoid Resistance Mechanisms That Increase p38 Activation in Cells. Learn More -
RWJ-67657
Catalog No. A13552 -
SB-242235
Catalog No. A13678 p38 MAPK inhibitorSB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases. Learn More -
SB 203580
Catalog No. A10824 p38 MAPK inhibitorSB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. Learn More -
SB 202190
Catalog No. A10823 p38 MAPK InhibitorSB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Learn More -
TAK-715
Catalog No. A11582 p38 MAPK inhibitorTAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε. Learn More -
VX-702
Catalog No. A10982 p38 MAPK inhibitorVX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM). Learn More -
Skepinone-L
Catalog No. A11321 p38 MAPK inhibitorSkepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Learn More -
PH-797804
Catalog No. A11078 p38 MAPK inhibitorPH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase. Learn More -
SB 203580 hydrochloride
Catalog No. A21526 p38 MAPK inhibitorSB 203580 hydrochloride (RWJ 64809 hydrochloride) is a widely used p38 MAPK inhibitor. Learn More -
TA-01
Catalog No. A16236 CK inhibitorTA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively). Learn More -
MW-150
Catalog No. A18798 p38α MAPK inhibitorMW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. Learn More -
TA-02
Catalog No. A13644 -
FR 167653 free base
Catalog No. A21110 p38 MAPK inhibitorFR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. Learn More -
LY2228820 (Ralimetinib)
Catalog No. A10545 p38 MAPK inhibitorLY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. Learn More -
MW-150 hydrochloride
Catalog No. A21854 p38α MAPK inhibitorMW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. Learn More -
MW-150 dihydrochloride dihydrate
Catalog No. A21860 p38α MAPK inhibitorMW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. Learn More -
BMS-582949 hydrochloride
Catalog No. A21914 p38α MAPK inhibitorBMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC50 of 13 nM. Learn More -
Ralimetinib
Catalog No. A21942 p38 MAPK α/β inhibitorRalimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. Learn More -
p38-α MAPK-IN-1
Catalog No. A21036 MAPK14 inhibitorp38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay. Learn More -
MAPK13-IN-1
Catalog No. A21038 MAPK13 (p38 δ) inhibitorMPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM. Learn More -
CMPD-1
Catalog No. A16040 p38 MAPK InhibitorCMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Learn More -
ML-3043
Catalog No. A12408 p38 MAPK inhibitorML-3043 is a p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively). Learn More -
VX-745
Catalog No. A10983 p38 MAPK inhibitorVX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ . Learn More -
Asiatic acid
Catalog No. A10092 Anti-inflammatory agentAsiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.
Learn More -
PD 169316
Catalog No. A11221 p38 MAPK inhibitorPD 169316 (PD169316) is a selective inhibitor of p38 MAPK.1 that inhibits p38 MAPK with an IC50 of 89 nM. Learn More -
Asiaticoside
Catalog No. A12021 Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns. Learn More -
SB 239063
Catalog No. A11562 p38 MAPK inhibitorSB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo. Learn More -
Dilmapimod
Catalog No. A13553 -
Pamapimod (R-1503)
Catalog No. A13551 p38 MAPK inhibitorPamapimod is a novel p38 mitogen-activated protein kinase inhibitor. Learn More -
Talmapimod (SCIO-469)
Catalog No. A12770 p38 MAPK inhibitorTalmapimod (SCIO-469) is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Learn More -
Losmapimod (GW856553X)
Catalog No. A12526 p38 MAPK inhibitorLosmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases. Learn More
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