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Tenovin-6
Catalog No. A12305 p53 activatorTenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively. Learn More -
PhiKan 083
Catalog No. A15350 p53 stabilizerPhiKan 083, p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Learn More -
NSC 146109 hydrochloride
Catalog No. A15349 p53 activatorNSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Learn More -
MIRA-1
Catalog No. A15348 p53 inducerMIRA-1 restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA. Learn More -
RETRA hydrochloride
Catalog No. A15351 mutant p53 ReactivatorRETRA hydrochloride is an antitumor agent which inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and iin vivo. Learn More -
p53 and MDM2 proteins-interaction-inhibitor racemic
Catalog No. A15202 p53-MDM2 interaction inhibitorp53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins. Learn More -
p53 and MDM2 proteins-interaction-inhibitor chiral
Catalog No. A15201 p53-MDM2 interaction inhibitorp53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins. Learn More -
SJ 172550
Catalog No. A15352 MDMX inhibitorSJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. Learn More -
WR 1065
Catalog No. A15353 P53/p21waf-1/MDM2 activatorWR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure. Learn More -
NSC 319726
Catalog No. A12930 p53R175 activatorNSC 319726 is a potent and selective activator of mutant p53R175 Learn More -
Pifithrin-u
Catalog No. A12449 p53 inhibitorinhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Learn More -
Pifithrin-beta
Catalog No. A12450 p53 InhibitorPifithrin-beta is a small molecule inhibitor of p53. Learn More -
Pifithrin-alpha
Catalog No. A12451 p53 inhibitorPifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Learn More -
JNJ 26854165
Catalog No. A10491 p53 activatorJNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias. Learn More -
Pifithrin-β
Catalog No. A22006 p53 inhibitorPifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM. Learn More -
NSC59984
Catalog No. A13413 P53 ActivatorNSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells. Learn More -
RG7112
Catalog No. A11523 selective p53-MDM2 inhibitorRG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. Learn More -
PK11007
Catalog No. A16833 p53 activatorPK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR. Learn More -
CBL-0137
Catalog No. A16836 p53 activator / NF-κB inhibitorCBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex). Learn More -
CP 31398 dihydrochloride
Catalog No. A15346 p53 stabilizerCP 31398 dihydrochloride, p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo. Learn More -
CP 31398 2HCl
Catalog No. A13522 p53 stabilizerCP 31398 2HCl has been shown to act as a stabilizing agent for p53, and to promotes activity of p53 in cancer cell lines. Learn More -
APR-246
Catalog No. A13636 APR-246 is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity. Learn More -
Kevetrin HCl
Catalog No. A13797 Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Learn More -
Tenovin-3
Catalog No. A13727 -
PRIMA-1
Catalog No. A13581 p53 reactivatorPRIMA-1 is a small molecule identified for its p53 reactivating effect. Learn More -
NSC348884
Catalog No. A13117 nucleophosmin inhibitorNSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. NSC 348884 is a putative inhibitor of nucleophosmin (NPM). NSC 348884 inhibits NMP oligomer formation, up-regulates p53 and induces apoptosis. Learn More -
Tenovin-1
Catalog No. A11943 p53 activatorTenovin-1 is a small molecule activator of p53 transcriptional activity that protects against MDM2-mediated p53 degradation. Learn More
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