p53

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  1. Pifithrin-alpha

    Catalog No. A12451
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    p53 inhibitor
    Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Learn More
  2. WR 1065

    Catalog No. A15353
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    P53/p21waf-1/MDM2 activator
    WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure. Learn More
  3. SJ 172550

    Catalog No. A15352
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    MDMX inhibitor
    SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. Learn More
  4. RETRA hydrochloride

    Catalog No. A15351
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    mutant p53 Reactivator
    RETRA hydrochloride is an antitumor agent which inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and iin vivo. Learn More
  5. PhiKan 083

    Catalog No. A15350
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    p53 stabilizer
    PhiKan 083, p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Learn More
  6. NSC 146109 hydrochloride

    Catalog No. A15349
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    p53 activator
    NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Learn More
  7. MIRA-1

    Catalog No. A15348
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    p53 inducer
    MIRA-1 restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA. Learn More
  8. p53 and MDM2 proteins-interaction-inhibitor racemic

    Catalog No. A15202
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    p53-MDM2 interaction inhibitor
    p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins. Learn More
  9. p53 and MDM2 proteins-interaction-inhibitor chiral

    Catalog No. A15201
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    p53-MDM2 interaction inhibitor
    p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins. Learn More
  10. Tenovin-6

    Catalog No. A12305
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    p53 activator
    Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively. Learn More
  11. NSC 319726

    Catalog No. A12930
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    p53R175 activator
    NSC 319726 is a potent and selective activator of mutant p53R175 Learn More
  12. Pifithrin-u

    Catalog No. A12449
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    p53 inhibitor
    inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Learn More
  13. APR-246

    Catalog No. A13636
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    APR-246 is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity. Learn More
  14. CP 31398 2HCl

    Catalog No. A13522
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    p53 stabilizer
    CP 31398 2HCl has been shown to act as a stabilizing agent for p53, and to promotes activity of p53 in cancer cell lines. Learn More
  15. CP 31398 dihydrochloride

    Catalog No. A15346
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    p53 stabilizer
    CP 31398 dihydrochloride, p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo. Learn More
  16. NSC59984

    Catalog No. A13413
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    P53 Activator
    NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells. Learn More
  17. RG7112

    Catalog No. A11523
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    selective p53-MDM2 inhibitor
    RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. Learn More
  18. Kevetrin HCl

    Catalog No. A13797
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    Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Learn More
  19. Tenovin-3

    Catalog No. A13727
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    p53 activator
    Tenovin-3 is a sirtuin inhibitor. Learn More
  20. PRIMA-1

    Catalog No. A13581
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    p53 reactivator
    PRIMA-1 is a small molecule identified for its p53 reactivating effect. Learn More
  21. NSC348884

    Catalog No. A13117
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    nucleophosmin inhibitor
    NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. NSC 348884 is a putative inhibitor of nucleophosmin (NPM). NSC 348884 inhibits NMP oligomer formation, up-regulates p53 and induces apoptosis. Learn More
  22. Pifithrin-beta

    Catalog No. A12450
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    p53 Inhibitor
    Pifithrin-beta is a small molecule inhibitor of p53. Learn More
  23. Tenovin-1

    Catalog No. A11943
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    p53 activator
    Tenovin-1 is a small molecule activator of p53 transcriptional activity that protects against MDM2-mediated p53 degradation. Learn More
  24. RITA (NSC 652287)

    Catalog No. A11931
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    p53 activator
    RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis. Learn More
  25. JNJ 26854165

    Catalog No. A10491
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    p53 activator
    JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias. Learn More
  26. CBL-0137

    Catalog No. A16836
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    p53 activator / NF-κB inhibitor
    CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex). Learn More

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